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Neuropediatrics 1991; 22(1): 33-35
DOI: 10.1055/s-2008-1071412
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Magnetic Resonance Imaging in Infantile Encephalopathy with Cerebral Calcification and Leukodystrophy*

E.  Boltshauser1 , M.  Steinlin1 , Ch.  Boesch1 , E.  Martin1 , G.  Schubiger2
  • 1Children's University Hospital, CH-8032 Zürich, Switzerland
  • 2Department of Pediatrics, Children's Hospital, CH-6000 Lucerne, Switzerland
* Supported by Swiss National Foundation No. 3.941-0.84 and 3.917-0.88
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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

Three children, one pair of siblings and a sporadic case, with "infantile (familial) encephalopathy with cerebral calcification and leukodystrophy" are reported. Neuroimaging studies demonstrated extensive bilateral calcifications particularly in paraventricular location and within the cerebral white matter. MRI, performed in two infants, confirmed marked white matter involvement with diffuse delay of myelination. This condition can be added to the growing list of leukodystrophies.

Key words

Leukodystrophy - Cerebral calcification - Magnetic resonance imaging - Computed tomography