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Thromb Haemost 2007; 97(01): 5-8
DOI: 10.1160/TH06-11-0670
Editorial Focus
Schattauer GmbH

Alternatively spliced tissue factor – One cut too many?

Nigel Mackman
1   Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, California, USA
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Publication History

Received 27 November 2006

Accepted 27 November 2006

Publication Date:
28 November 2017 (online)

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  • References

  • 1 Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004; 24: 1015-1022.
    CrossrefPubMedGoogle Scholar
  • 1 Mackman N, Morrissey JH, Fowler B. et al Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 1989; 28: 1755-1762.
    CrossrefPubMedGoogle Scholar
  • 1 Ruf W, Schullek JR, Stone MJ. et al Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochemistry 1994; 33: 1565-1572.
    CrossrefPubMedGoogle Scholar
  • 1 Muller YA, Ultsch MH, Kelley RF. et al Structure of the extracellular domain of human tissue factor: Location of the factor VIIa binding site. Biochemistry 1994; 33: 10864-10870.
    CrossrefPubMedGoogle Scholar
  • 1 Banner DW, D'Arcy A, Chene C. et al The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-46.
    CrossrefPubMedGoogle Scholar
  • 1 Ruf W, Miles DJ, Rehemtulla A. et al Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J Biol Chem 1992; 267: 6375-6381.
    CrossrefPubMedGoogle Scholar
  • 1 Roy S, Hass PE, Bourell JH. et al Lysine residues 165 and 166 are essential for the cofactor function of tissue factor. J Biol Chem 1991; 266: 22063-22066.
    CrossrefPubMedGoogle Scholar
  • 1 Huang Q, Neuenschwander PF, Rezaie AR. et al Substrate recognition by tissue factor-factor VIIa. Evidence for interaction of residues Lys165 and Lys166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem 1996; 271: 21752-21757.
    CrossrefPubMedGoogle Scholar
  • 1 Huang M, Syed R, Stura EA. et al The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. J Mol Biol 1998; 275: 873-894.
    CrossrefPubMedGoogle Scholar
  • 1 Kirchhofer D, Moran P, Chiang N. et al Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies. Thromb Haemost 2000; 84: 1072-1081.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Ohto U, Mizutani R, Nakamura M. et al Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor. J Synchrotron Radiat 2004; 11: 105-108.
    CrossrefPubMedGoogle Scholar
  • 1 Chen VM, Ahamed J, Versteeg HH. et al Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry 2006; 45: 12020-12028.
    CrossrefPubMedGoogle Scholar
  • 1 Norledge BV, Petrovan RJ, Ruf W. et al The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis. Proteins 2003; 53: 640-648.
    CrossrefPubMedGoogle Scholar
  • 1 Chen SW, Pellequer JL, Schved JF. et al Model of a ternary complex between activated factor VII, tissue factor and factor IX. Thromb Haemost 2002; 88: 74-82.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Ruf W, Rehemtulla A, Edgington TS. Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem 1991; 266: 2158-2166.
    CrossrefPubMedGoogle Scholar
  • 1 Neuenschwander PF, Morrissey JH. Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. J Biol Chem 1992; 267: 14477-14482.
    CrossrefPubMedGoogle Scholar
  • 1 Paborsky LR, Caras IW, Fisher KL. et al Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor. J Biol Chem 1991; 266: 21911-21916.
    CrossrefPubMedGoogle Scholar
  • 1 Morrissey JH, Neuenschwander PF, Huang Q. et al Factor VIIa-tissue factor: functional importance of protein-membrane interactions. Thromb Haemost 1997; 78: 112-116.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Waxman E, Ross JBA, Laue TM. et al Tissue factor and its extracellular soluble domain: The relationship between intermolecular association with factor VIIa and enzymatic activity of the complex. Biochemistry 1992; 31: 3998-4003.
    CrossrefPubMedGoogle Scholar
  • 1 Fiore MM, Neuenschwander PF, Morrissey JH. The biochemical basis for the apparent defect of soluble mutant tissue factor in enhancing the proteolytic activities of factor VIIa. J Biol Chem 1994; 269: 143-149.
    CrossrefPubMedGoogle Scholar
  • 1 Garcia-Blanco MA. Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing. J Clin Invest 2003; 112: 474-480.
    CrossrefPubMedGoogle Scholar
  • 1 Crossman DC, Carr DP, Tuddenham EGD. et al The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. J Biol Chem 1990; 265: 9782-9787.
    CrossrefPubMedGoogle Scholar
  • 1 Brand K, Fowler BJ, Edgington TS. et al Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide. Mol Cell Biol 1991; 11: 4732-4738.
    CrossrefPubMedGoogle Scholar
  • 1 van der Logt CPE, Reitsma PH, Bertina RM. Alternative splicing is responsible for the presence of two tissue factor mRNA species in LPS stimulated human monocytes. Thromb Haemost 1992; 67: 272-276.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Chand HS, Ness SA, Kisiel W. Identification of a novel human tissue factor splice variant that is upregulated in tumor cells. Int J Cancer 2006; 118: 1713-1720.
    CrossrefPubMedGoogle Scholar
  • 1 Bogdanov VY, Balasubramanian V, Hathcock J. et al Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 2003; 9: 458-462.
    CrossrefPubMedGoogle Scholar
  • 1 Guo W, Wang H, Zhao W. et al Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. Chin Med J (Engl ) 2001; 114: 30-34.
    PubMedGoogle Scholar
  • 1 Szotowski B, Antoniak S, Poller W. et al Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. Circ Res 2005; 96: 1233-1239.
    CrossrefPubMedGoogle Scholar
  • 1 Szotowski B, Goldin-Lang P, Antoniak S. et al Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. J Am Coll Cardiol 2005; 45: 1081-1089.
    CrossrefPubMedGoogle Scholar
  • 1 Yu JL, May L, Lhotak V. et al Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 2005; 105: 1734-1741.
    CrossrefPubMedGoogle Scholar
  • 1 Bogdanov VY, Kirk I R, Miller C. et al Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost 2006; 4: 158-167.
    CrossrefPubMedGoogle Scholar
  • 1 Bruggemann LW, Drijfhout JW, Reitsma PH. et al Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae. J Thromb Haemost 2006; 4: 918-20.
    CrossrefPubMedGoogle Scholar
  • 1 Young JL, Libby P, Schönbeck U. Cytokines in the pathogenesis of atherosclerosis. Thromb Haemost 2002; 88: 554-67.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Censarek P, Bobbe A, Schror K. et al Alternatively spliced human tissue factor (asHTF) is not procoagulant. Thromb Haemost 2007; 97: 11-14.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 1 Hedner U. NovoSeven as a universal haemostatic agent. Blood Coagul Fibrinolysis 2000; 11 (Suppl. 01) S107-S111.
    CrossrefPubMedGoogle Scholar
  • 1 Butenas S, Bouchard BA, Brummel-Ziedins KE. et al Tissue factor activity in whole blood. Blood 2005; 105: 2764-70.
    CrossrefPubMedGoogle Scholar
  • 1 Kelley RF, Refino CJ, O'Connell MP. et al A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent. Blood 1997; 89: 3219-27.
    CrossrefPubMedGoogle Scholar