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Thromb Haemost 2011; 105(05): 802-810
DOI: 10.1160/TH10-11-0735
Theme Issue Article
Schattauer GmbH

Intravital imaging of phagocyte recruitment

Remco T. A. Megens
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany
2   Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Germany
3   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany
,
Klaus Kemmerich
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany
3   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany
,
Juergen Pyta
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany
,
Christian Weber
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany
3   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany
4   Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
,
Oliver Soehnlein
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany
3   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany
4   Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 16 November 2010

Accepted after major revision: 02 March 2011

Publication Date:
28 November 2017 (online)

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Summary

Extravasation of neutrophils and monocytes is a hallmark event in acute and chronic inflammation. Owing to recent improvements in optical imaging techniques, the classical leukocyte extravasation cascade has been refined with intermediate steps being added. Further studies have shown tissue specific leukocyte recruitment patterns, thus allowing for more selective targeting. Here we focus on recent advances in intravital imaging of leukocyte recruitment by means of optical imaging techniques and emphasise the translation thereof into tissue-specific recruitment to the lungs, the liver and large arteries.

Keywords

Imaging - leukocyte trafficking / recruitment - cell migration - inflammation
 

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