Oligodendrogliom mit neuronaler Differenzierung bei einem 8 Monate alten Afrikanischen Weißbauchigel (Atelerix albiventris)

Zusammenfassung

Ein 8 Monate alter, männlicher Afrikanischer Weißbauchigel zeigte klinisch einen schwankenden Gang, Anurie, Inappetenz und Apathie, woraufhin die Verdachtsdiagnose Wobbly Hedgehog Syndrome gestellt wurde. Nach Exazerbation wurde der Igel euthanasiert. Der histologisch im Großhirn nachgewiesene Tumor bestand überwiegend aus mittelgroßen, ovoiden Zellen und einer in geringerer Zahl vorhandenen spindelzelligen Zellpopulation. Im Tumor fanden sich Neuropil-Inseln und extrazelluläres myxoides Material. Immunhistochemisch exprimierten die Tumorzellen sowohl oligodendrogliale (neuritic outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) als auch neuronale (neuronenspezifische Enolase, NSE; microtubuleassociated protein-2a, MAP-2a; Synaptophysin) Zellmarker. Anhand der Befunde wurde die Diagnose eines Oligodendroglioms mit neuronaler Differenzierung gestellt, wobei es sich um einen bei Weißbauch - igeln bisher nicht beschriebenen Hirntumor handelt. Die bei der Obduktion festgestellte hochgradige Füllung und Dilatation der Harnblase wurde vermutlich durch eine tumorbedingte zentrale Blockade des Blasenentleerungszentrums hervorgerufen. Auch bei jungen Igeln sollte im Fall neurologischer Symptome an einen primären Gehirntumor gedacht werden. Differenzialdiagnostisch sind entzündlich-infektiöse (Tollwut, Herpes, Baylisaskariose), degenerative (Kardiomyopathie, Bandscheibenerkrankung), traumatische, alimentäre (Vitamin-B-Mangel) und metabolisch-toxische (Hitze-Kälte-Starre, hepatische Enzephalopathie) Noxen auszuschließen.

Summary

An 8-month-old, male African hedgehog clinically displayed a wobbly walk, anuria, inappetence and apathy, whereupon the suspected diagnosis wobbly hedgehog syndrome was made. After exacerbation, the hedgehog was euthanized. Histologically, a tumour mainly consisting of medium-sized, oval tumour cells and a smaller number of spindeloid cells was found in the cerebrum. The tumour contained neuropil islets and extracellular myxoid material. Immunohistochemically, the tumour cells expressed oligodendroglial (neurite outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) and neuronal (neuron-specific enolase, NSE; microtubule-associated protein-2a, MAP-2a; synaptophysin) cell markers. Based on these findings, an oligodendroglioma with neuronal differentiation was diagnosed. Such a brain tumour has to date not been reported for African hedgehogs. At necropsy, a severely filled and dilated urinary bladder was observed, which was presumably caused by a central blockade of the micturition centre in the brain. In the case of neurological symptoms in young hedgehogs, a primary brain tumour should, as in adults, be considered as a differential diagnosis. As further differentials, inflammatory-infectious (rabies, herpes, baylisascariosis), degenerative (cardiomyopathy, intervertebral-disc disease), traumatic, alimentary (vitamin-B deficiency) and metabolic-toxic (heat-cold-torpor, hepatic encephalopathy) triggers have to be considered.

Schlüsselwörter

Neoplasie - Tumor - Igel - juvenil - Gehirn - ZNS - Wobbly Hedgehog Syndrome

Keywords

Neoplasm - tumour - hedgehog - juvenile - brain - CNS - wobbly hedgehog syndrome

• Literatur

• 1 Allison N, Chang TC, Steele KE, Hillirad JK. Fatal herpes simplex infection in a pygmy African hedgehog (Atelerix albiventris). J Comp Path 2002; 126: 76-78.
• 2 Baumgärtner W, Wohlsein P. Nervensystem. Spezielle Pathologie für die Tiermedizin.. Baumgärtner W, Gruber AD. Stuttgart: Enke; 2015: 259-309.
• 3 Benneter SS, Summers BA, Schulz-Schaeffer WJ, Härtig W, Mollidor J, Schöniger S. Mixed glioma (oligoastrocytoma) in the brain of an African Hedgehog (Atelerix albiventris). J Comp Path 2014; 151: 420-424.
• 4 Brosinski K, Janik D, Polkinghorne A, Von Bomhard W, Schmahl W. Olfactory neuroblastoma in dogs and cats - a histological and immunohistological analysis. J Comp Path 2012; 146: 152-159.
• 5 Döpke C. Kasuistische Auswertung der Untersuchungen von Igeln (Erinaceus europaeus) im Einsendungsmaterial des Institutes für Pathologie von 1980 bis 2001. Dissertation, Tierärztliche Hochschule Hannover. 2002: 47-50.
• 6 Döpke C, Gröne A, Borstel MV, Oppen TV, Boéve MH, Baumgärtner W. Metastatic esthesioneuroblastoma in a horse. J Comp Path 2005; 132: 218-222.
• 7 Done LB, Dietze M, Cranfield M, Ialeggio D. Necropsy lesions by body systems in African hedgehogs (Atelerix albiventris): Clues to clinical diagnosis. Proceedings of the Annual joint conference of the Association of Avian Veterinarians and the Association of Exotic Mammal Veterinarians, Oakland. 1992: 110-112.
• 8 Gardhouse S, Eshar D. Retrospective study of disease occurrence in captive African pygmy hedgehogs (Atelerix albiventris). Isr J Vet Med 2015; 70: 32-36.
• 9 Garner MM, Kiupel M, Munoz JF. Brain tumors in African Hedgehogs (Atelerix albiventris). Proceedings of the Annual joint conference of the Association of Avian Veterinarians and the Association of Exotic Mammal Veterinarians. San Diego: 2010: 65.
• 10 Gibson CJ, Parry NMA, Jakowski RM, Eshar D. Anaplastic astrocytoma in the spinal cord of an African Pygmy Hedgehog (Atelerix albiventrans). Vet Pathol 2008; 45: 934-938.
• 11 Heide S. Neuronale Differenzierung in Oligodendrogliomen. Dissertation. Medizinische Fakultät Charité - Universitätsmedizin Berlin; 2007
• 12 Huisinga M, Henrich M, Frese K, Burkhardt E, Kuchelmeister K, Schmidt M, Reinacher M. Extraventricular neurocytoma of the spinal cord in a dog. Vet Pathol 2008; 45: 63-66.
• 13 Graesser D, Spraker TR, Dressen P, Garner MM, Raymond JT, Terwilliger G, Kim J, Madri JA. Wobbly hedgehog syndrome in African pygmy hedgehogs (Atelerix spp.). J Exotic Pet Med 2006; 15: 59-65.
• 14 Hoefer HL. Clinical approach to the African hedgehog. Proceedings of the North American Veterinary Conference. Florida: 1999: 836-837.
• 15 Ivey E, Carpenter JW. African hedgehogs. Ferrets, Rabbits, and Rodents - Clinical Medicine and Surgery.. Quesenberry KE, Carpenter JW. St. Louis: Elsevier; 2012: 411-427.
• 16 Jeffs GJ, Lee GY, Wong GT. Spinal cord ganglioglioma presenting as acute paraparesis. Clin Neurol Neurosurg 2006; 108: 503-506.
• 17 Johnson D. African pygmy hedgehogs. BSAVA Manual of Exotic Pets.. Meredith A, Johnson-Delaney C. Gloucester: Quedgeley; 2010: 139-147.
• 18 Koestner A, Bilzer T, Fatzer R, Schulman FY, Summers BA, Van Winkle TJ. Histological Classification of Tumors of the Nervous System of Domestic Animals. Washington, DC. Armed Forces Institute of Pathology in cooperation with the American Registry of Pathology and the World Health Organization Collaborating Center for Worldwide Reference on Comparative Oncology. 1999: 13-15.
• 19 Kuhlmann T, Remington L, Maruschak B, Owens T, Brück W. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. J Neuropathol Exp Neurol 2007; 66: 238-246.
• 20 Lightfoot TL. Therapeutics of African pygmy hedgehogs and praerie dogs. Vet Clin North Am Exot Anim Pract 2000; 3: 155-172.
• 21 Madrame H, Ogihara K, Kimura M, Nagai M, Omatsu T, Ochiai H, Mizutani T. Detection of a pneumonia virus of mice (PVM) in an African hedgehog (Atelerix albiventris) with suspected wobbly hedgehog syndrome. Vet Microbiol 2014; 173: 136-140.
• 22 Nakata M, Miwa Y, Itou T, Uchida K, Nakayama H, Sakai T. Astrocytoma in an African Hedgehog (Atelerix albiventris) suspected Wobbly Hedgehog Syndrome. J Vet Med Sci 2011; 73: 1333-1335.
• 23 Nyska A, Shamir MH, Harmelin A, Sandbank J, Waner T. Intracranial gangliocytoma in a dog. Vet Pathol 1995; 32: 190-192.
• 24 Raymond JT, White MR. Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris): a retrospective study. J Zoo Wildl Med 1999; 30: 273-277.
• 25 Raymond JT, Garner MM. Spontaneus tumors in captive African hedgehogs (Atelerix albiventris): a retrospective study. J Comp Path 2001; 124: 128-133.
• 26 Raymond JT, Aguilar R, Dunker F, Ochsenreiter J, Nofs S, Shellabarger W, Garner MM. Intervertebral disc disease in African hedgehogs (Atelerix albiventris): four cases. J Exot Pet Med 2009; 18: 220-223.
• 27 Rissi DR, Levine JM, Eden KB, Watson VE, Griffin IV JF, Edwards JF, Porter BF. Cerebral oligodendroglioma mimicking intraventricular neoplasia in three dogs. J Vet Diagn Invest 2015; 27: 396-400.
• 28 Robinson I, Routh A. Veterinary care of the hedgehog. In Pract 1999; 21: 139-143.
• 29 Rossmeisl Jr JH, Piñeyro P, Sponenberg DP, Garman RH, Jortner BS. Clinicopathologic features of intracranial central neurocytomas in 2 dogs. J Vet Intern Med 2012; 26: 186-191.
• 30 Schwab ME. Nogo and axon regeneration. Curr Opin Neurobiol 2004; 14: 118-124.
• 31 Ulrich R, Stan AC, Fehr M, Mallig C, Puff C. Desmoplastic ganglioglioma of the spinal cord in a western European hedgehog (Erinaceus europaeus). J Vet Diagn Invest 2010; 22: 978-983.
• 32 Vandevelde M, Higgins R, Oevermann A. Veterinary Neuropathology: Essentials of Theory and Practice.. Hoboken, New Jersey: Wiley-Blackwell; 2012
• 33 Yokoo HI, Nobusawa S, Takebayashi H, Ikenaka K, Isoda K, Kamiya M, Sasaki A, Hirato J, Nakazato Y. Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Am J Pathol 2004; 164: 1717-1725.