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Planta Med 2015; 81(06): 533-540
DOI: 10.1055/s-0034-1396139
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products

Maria Concetta Gidaro
1   Dipartimento di Scienze della Salute, Università “Magna Graecia” di Catanzaro, Campus “S. Venuta”, Catanzaro, Italy
,
Francesca Alcaro
1   Dipartimento di Scienze della Salute, Università “Magna Graecia” di Catanzaro, Campus “S. Venuta”, Catanzaro, Italy
,
Simone Carradori
2   Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy
,
Giosuè Costa
1   Dipartimento di Scienze della Salute, Università “Magna Graecia” di Catanzaro, Campus “S. Venuta”, Catanzaro, Italy
,
Daniela Vullo
3   Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy
,
Claudiu T. Supuran
3   Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy
,
Stefano Alcaro
1   Dipartimento di Scienze della Salute, Università “Magna Graecia” di Catanzaro, Campus “S. Venuta”, Catanzaro, Italy
› Author Affiliations
Further Information

Publication History

received 03 July 2014
revised 06 October 2014

accepted 22 November 2014

Publication Date:
15 January 2015 (online)

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Erratum for: Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural ProductsPlanta Med 2015; 81(06): E1-E1
DOI: 10.1055/s-0034-1396263

Abstract

In this work, we performed a structure-based virtual screening against five carbonic anhydrase isoforms using, as a ligand library, natural components of Citrus bergamia (Bergamot) and Allium cepa var. Tropea (red onion) sources, which are some typical Calabrian products. The most relevant Bergamot and red onion components, identified as potentially new hits by means of the computational work, were submitted to in vitro tests in order to confirm the ability to exert the predicted biological activity. Apigenin and eriocitrin were identified as new potent inhibitors of human carbonic anhydrase VA isozyme.

Key words

Citrus bergamia - Rutaceae - Allium cepa var. Tropea - Liliaceae - flavonoids - docking - structure-based virtual screening - human carbonic anhydrase inhibition

Supporting Information

 

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