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Planta Med 2015; 81(10): 847-854
DOI: 10.1055/s-0035-1546127
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1

Hao Wang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Chang-An Geng
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Hong-Bo Xu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Xiao-Yan Huang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Yun-Bao Ma
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Cai-Yan Yang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Xue-Mei Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Ji-Jun Chen
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 05 December 2014
revised 11 March 2015

accepted 22 April 2015

Publication Date:
17 June 2015 (online)

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Abstract

Investigation on the fruits of Melia toosendan afforded seven new lignans (1–7), along with seventeen known compounds (8–24). The structures of the new compounds, involving four neo-lignans (1–4), two sesquilignans (5–6), and a nor-lignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77 % at 1.02 mM according to the assay on HEK293 cell lines in vitro.

Key words

Melia toosendan - Meliaceae - lignans - MT1 receptor - agonistic activity

Supporting Information

 

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