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Planta Med 1994; 60(3): 214-217
DOI: 10.1055/s-2006-959461
Paper

© Georg Thieme Verlag Stuttgart · New York

Pharmacokinetics of the Garlic Compound S-Allylcysteine

S. Nagae1 , M. Ushijima1 , S. Hatono1 , J. Imai1 , S. Kasuga1 , H. Matsuura1 , Y. Itakura1 , Y. Higashi2
  • 1Institute for OTC Research, Wakunaga Pharmaceutical Co., Ltd., 1624 Shimokotachi, Koda-cho, Takata-gun, Hiroshima 729-64, Japan
  • 2Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima 734, Japan
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The pharmacokinetic behavior of S-allylcysteine (SAC), one of the biologically active transformation products from garlic, was investigated after oral administration to rats, mice, and dogs. SAC was rapidly and easily absorbed in the gastrointestinal tract and distributed mainly in plasma, liver, and kidney. The bioavailability was 98.2, 103.0, and 87.2% in rats, mice, and dogs, respectively. SAC was mainly excreted into urine in the N-acetyl form in rats; however, mice excreted both SAC and the N-acetyl form. The half-life of SAC was longer in dogs than in rats and mice.

Key words

Allium sativum - Alliaceae - S-allylcysteine - pharmacokinetics - N-acetyl-S-allylcysteine - garlic

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