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Synthesis 2010(15): 2577-2582  
DOI: 10.1055/s-0029-1218815
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Approach for C-C Bond Formation through Ruthenium-Amido Complex Catalyzed Tandem Aldol Reaction/Hydrogenation

Haifeng Sun, Deju Ye, Hualiang Jiang, Kaixian Chen, Hong Liu*
The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201203, P. R. of China
Fax: +86(21)50807088; e-Mail: hliu@mail.shcnc.ac.cn;
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Publication History

Received 7 January 2010
Publication Date:
15 June 2010 (online)

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Abstract

A one-pot novel and efficient approach was developed for the α-alkylation of various nitriles with carbonyl compounds using ruthenium-amido complex catalyst 1. The C-C bond was formed through aldol reaction followed by hydrogenation with triethylamine-formic acid (TEAF) and 1. Moderate to high yields were obtained, and a variety of functional groups were tolerated, including nitro and chloro groups, and a furan ring.

Key words

ruthenium-amido complex - tandem reaction - aldol reaction - hydrogenation - C-C bond

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