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Synthesis 2010(15): 2577-2582
DOI: 10.1055/s-0029-1218815
DOI: 10.1055/s-0029-1218815
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
One-Pot Approach for C-C Bond Formation through Ruthenium-Amido Complex Catalyzed Tandem Aldol Reaction/Hydrogenation
Further Information
Received
7 January 2010
Publication Date:
15 June 2010 (online)
Publication History
Publication Date:
15 June 2010 (online)
Abstract
A one-pot novel and efficient approach was developed for the α-alkylation of various nitriles with carbonyl compounds using ruthenium-amido complex catalyst 1. The C-C bond was formed through aldol reaction followed by hydrogenation with triethylamine-formic acid (TEAF) and 1. Moderate to high yields were obtained, and a variety of functional groups were tolerated, including nitro and chloro groups, and a furan ring.
Key words
ruthenium-amido complex - tandem reaction - aldol reaction - hydrogenation - C-C bond
- Supporting Information for this article is available online:
- Supporting Information
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