Transition-Metal-Catalyzed Synthesis of 1,3-Diynes and Ynamides from 2-Bromo-1-iodoalkenes

Abstract

Diynes and ynamides are important products in chemical synthesis. An efficient palladium-catalyzed homocoupling reaction of 2-bromo-1-iodoalkenes to give 1,3-diynes has been developed. The reactions are conducted under convenient conditions and provide products in moderate to excellent yields. Moreover, ynamides were synthesized from 2-bromo-1-iodoalkenes and carbamates, and it is noteworthy that this reaction is catalyzed by nanoparticulate copper(I) oxide to give ynamides in high yields.

Key words

catalysis - palladium - copper - alkynes - amides - coupling

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