Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596718
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Effect of germination on in vitro and in vivo activity of Lupinus albus L. and Lupinus angustifolius L. seed extract

Authors

  • C Danciu

    1   Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

  • E Alexa

    2   Department of Food Control, Banat's University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania”from Timisoara, Calea Aradului no.119, 300641, Timisoara, România

  • I Zupko

    3   Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6., Szeged H-6720, Hungary

  • S Avram

    1   Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

  • I Zinuca Pavel

    1   Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

  • D Minda

    1   Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

  • G Pop

    4   Department of Plant culture, Banat's University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Calea Aradului no.119, 300641, Timisoara, România

  • D Coricovac

    5   Department of Toxicology, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România

  • C Dehelean

    5   Department of Toxicology, University of Medicine and Pharmacy “Victor Babeş“, Eftimie Murgu Square, No. 2, 300041 Timişoara, România
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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Nutraceuticals have lately been in the spotlight of research due to their significant contribution to the natural prevention of various health issues [1]. Lupinus albus L., commonly known as the white lupin, and Lupinus angustifolius L., commonly known as the narrow-leafed lupin or blue lupin, both included in the Fabaceae family, are two plant species known as nutraceuticals for their seeds. The Lupinus genus comprises over 200 species that contain approximately 36 – 52% proteins, 30 – 40%, fibers and 5 – 20% oil depending on the environmental or genetic conditions [2, 3]. Ethanolic extracts from the ungerminated and germinated seeds of Lupinus albus L. and Lupinus angustifolius L. were analyzed in terms of the content in total phenols, isoflavones and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial (against 5 bacterial strains: Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 700603), Staphylococcus epidermidis (ATCC 14990)), antiproliferative (four cancer cell lines: MCF7, MDA-MB-231 (breast cancers), A2780 (ovarian cancer) and SiHa (cervical cancer)) and antiinflammatory properties (ear model of inflammation), using in vitro and in vivo tests. Results have shown that germination is a method of choice in increasing the amount of total polyphenols, isoflavones and cinnamic acid derivatives in both Lupinus albus L. and Lupinus angustifolius L. seeds. However, biological evaluation of the antimicrobial, antiproliferative, anti-inflammatory activity of all vegetal extracts revealed an overall weak potential for both ungerminated and germinated seeds.

Keywords: Lupinus albus, Lupinus angustifolius, polyphenols, antibacterial, antiproliferative, anti-inflammatory.

References:

[1] Rahal AM. Phytonutrients and nutraceuticals in vegetables and their multi-dimensional medicinal and health benefits for humans and their companion animals: A review. J Biol Sci 2014; 14: 1 – 19

[2] Akritidu KP, Boinik VV, Demeshko OV. Organic acids from Lupinus polyphyllus roots. Chem Nat Compd 2013; 49: 501 – 502

[3] Mohamed AA, Rayas-Duarte P. Composition of Lupinus albus. Cereal Chem 1995; 72: 643 – 647


No conflict of interest has been declared by the author(s).