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Synthesis 2019; 51(04): 885-888
DOI: 10.1055/s-0037-1610667
DOI: 10.1055/s-0037-1610667
paper
Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one
This work was supported by the National Research Foundation of Korea (NRF-2012M3A7B4049645 and 2014R1A5A1011165 with the Centre for New Directions in Organic Synthesis).Further Information
Publication History
Received: 27 August 2018
Accepted after revision: 09 October 2018
Publication Date:
08 November 2018 (online)
Abstract
The asymmetric synthesis of (3R,5S)-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one, as the most potent selective inactivator of monoamine B, was successfully achieved by applying a newly developed synthetic method toward the key γ-aminomethyl-γ-lactone via intramolecular aziridine ring opening in 63% overall yield from a commercial starting material.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610667.
- Supporting Information
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