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Synthesis 2019; 51(04): 889-898
DOI: 10.1055/s-0037-1610668
DOI: 10.1055/s-0037-1610668
paper
Metal-Free Blue-Light-Mediated Cyclopropanation of Indoles by Aryl(diazo)acetates
This work was supported by the National Natural Science Foundation of China (Nos. 21772179, 21502173, 21672192) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316002).Further Information
Publication History
Received: 12 September 2018
Accepted after revision: 10 October 2018
Publication Date:
20 November 2018 (online)
Abstract
Blue-light-mediated cyclopropanation of indoles with aryl(diazo)acetates has been developed. The salient features of this strategy are that it is metal-free, operationally simple and atom-efficient, and that it uses an environmentally friendly energy source. In this protocol, blue light was employed as the sole energy source for the transformation. A variety of cyclopropane-fused indoline compounds was obtained in moderate to excellent yields and high diastereoselectivities under mild conditions.
Key words
metal-free - blue light - cyclopropanation - indoles - diazo compounds - aryl(diazo)acetateSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610668.
- Supporting Information
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For selective visible-light-induced functionalization, see:
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