Diastereoselective Synthesis of Cyclic sp³-Enriched cis-β-Alkoxysulfonyl Chlorides

Abstract

A three-step synthesis of β-alkoxy-substituted alicyclic sulfonyl chlorides from cyclic alkenes and alcohols is reported. The scope of the method was studied for a range of the substrates with various steric and electronic properties. The title compounds were obtained on a hundred-gram scale in up to 52% overall yield scale as single cis-diastereomers.

Key words

organosulfur compounds - alicyclic compounds - heteroaliphatic compounds - sulfonyl chlorides - building blocks

• References

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