Planta Med 2019; 85(18): 1499-1500
DOI: 10.1055/s-0039-3399925
Main Congress Poster
Poster Session 1
© Georg Thieme Verlag KG Stuttgart · New York

Phytochemical investigation of Cyperus malaccensis subsp. monophyllus

M Hibi
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, 501-1196, Gifu JAPAN
,
N Abe
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, 501-1196, Gifu JAPAN
,
M Haba
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, 501-1196, Gifu JAPAN
,
T Tanaka
2   Laboratory of Natural Resources, Gifu Pharmaceutical University,, 1–25–4 Daigaku-nishi, Gifu, Gifu 501-1196, JAPAN
,
H Murata
3   Setsunan University,, Faculty of Pharmaceutical Sciences, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JAPAN
,
M Oyama
1   Gifu Pharmaceutical University,, Laboratory of Pharmacognosy, Department of Biomolecules, 1–25–4 Daigaku-nishi, Gifu, 501-1196, Gifu JAPAN
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

 
 

The genus Cyperus belongs to the family Cyperaceae with approximately 600 species distributed in China, Indonesia, Japan, and Vietnam. Some of Cyperus plants are used in folk medicine. Rhizomes of Cyperus rotundus, for example, have been used in traditional Chinese medicine and Japanease ‘Kampo’ medicine as estrogenic and anti-inflammatory agents for the treatment of menstrual disorders, stomachache, and bowel disorders [1]. Coumarins [2], quinones [3], benzofurans [4], aurones [5], sesquiterpenes [6], and flavonoids [7] have been reported from Cyperus species. Herein, we describe our exploration of the chemical diversity within Cyperus malaccensis subsp. monophyllus, and report the isolation and the structural elucidation of several compounds.

Air-dried and powdered aerial part (3.5 kg) of C. malaccensis subsp. monophyllus were extracted with Acetone (5 x 22 L) at room temperature to yield the crude extract (49 g). A part of extract was separated by repeated column chromatography (CC), including silica gel CC (Si-CC), Sephadex LH-20 CC, octadecylsilanized silica gel (ODS) CC, and preparative HPLC to yield 11 known compounds. Their structures were elucidated through extensive spectroscopic methods, including 1D and 2D NMR experiments and MS spectra analyses.


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  • References

  • 1 Zhou Z, Zhang H. Phenolic and iridoid glycosides from the rhizomes of Cyperus rotundus L. Med Chem Res 2013; 22: 4830-4835.
    CrossrefPubMedGoogle Scholar
  • 2 Awaad AS, Zain ME. Cyperus alopecuroides: coumarins and antimicrobial activity. Egypt J Pharm Sci 2001; 40: 107-116.
    PubMedGoogle Scholar
  • 3 Morimoto M, Fujii Y, Komai K. Antifeedants in cyperaceae: coumaran and quinones from Cyperus spp. Phytochem 1999; 51: 605-608.
    CrossrefPubMedGoogle Scholar
  • 4 Morimoto M, Urakawa M, Fujitaka T, Komai K. Structure-activity relationship for the insect antifeedant activity of benzofuran derivatives. Biosci Biotechnol Biochem 1999; 63: 840-846.
    CrossrefPubMedGoogle Scholar
  • 5 Seabra RM, Silva AMS, Andrade PB, Moreira MM. Methylaurones from Cyperus capitatus . Phytochem 1998; 48: 1429-1432.
    CrossrefPubMedGoogle Scholar
  • 6 Xu F, Morikawa T, Matsuda H, Ninomiya K, Yoshikawa M. Structures of New Sesquiterpenes and Hepatoprotective Constituents from the Egyptian Herbal Medicine Cyperus longus . J Nat Prod 2004; 67: 569-576.
    CrossrefPubMedGoogle Scholar
  • 7 AF Abdel-Razik, MI Nassar, E-DA EK, A-AM D, Mabry TJ. New prenylflavans from Cyperus conglomeratus . Fitoterapia 2005; 76: 762-764.
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