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Synthesis 2022; 54(03): 705-710
DOI: 10.1055/s-0040-1720907
DOI: 10.1055/s-0040-1720907
paper
Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C–N Bond Cleavage
The authors gratefully acknowledge the support of Science and Technology Planning Project of Guangdong Province (2017A010103017), National Natural Science Foundation of China (21272080, 51703069), and Special Innovation Projects of Common Universities in Guangdong Province (20178S0182).
Abstract
Palladium-catalyzed Hiyama coupling of active thioureas via selective C–N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.
Key words
desulfurative Hiyama coupling - CuF2 activator - thiourea - selective C–N bond cleavage - amideSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1720907.
- Supporting Information
Publication History
Received: 03 August 2021
Accepted after revision: 13 September 2021
Article published online:
14 October 2021
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