Synthesis 2005(12): 1949-1954  
DOI: 10.1055/s-2005-869959
PAPER
© Georg Thieme Verlag Stuttgart · New York

An Efficient and Practical Process for the Synthesis of Bis(indolyl)methanes Catalyzed by Zirconium Tetrachloride

Zhan-Hui Zhang, Liang Yin, Yong-Mei Wang*
Department of Chemistry and the State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China
Fax: +86(22)23502654; e-Mail: zhanhui@mail.nankai.edu.cn;
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Publikationsverlauf

Received 24 December 2004
Publikationsdatum:
24. Juni 2005 (online)

Abstract

Zirconium tetrachloride is used as a catalyst for the electrophilic substitution reaction of indole with aldehydes or ketones at ambient temperature to afford the corresponding bis(indolyl)methanes in good to excellent yields.