Synthesis 2007(1): 33-38  
DOI: 10.1055/s-2006-950368
PAPER
© Georg Thieme Verlag Stuttgart · New York

A General Synthesis of Furo[3,2-c][1,2,4]triazolo[1,5-a]azepine and Furo[2,3-f][1,2,4]triazolo[1,5-a]azepine Derivatives

Qingqing Meng, Hexiang Bai, Quanrui Wang*, Fenggang Tao
Department of Chemistry, Fudan University, 200433 Shanghai, P. R. of China
Fax: +86(21)65641740; e-Mail: qrwang@fudan.edu.cn;
Further Information

Publication History

Received 26 July 2006
Publication Date:
13 November 2006 (online)

Abstract

Derivatives of two new heterocyclic systems, namely furo­[3,2-c][1,2,4]triazolo[1,5-a]azepinium salts and furo[2,3-f][1,2,4]triazolo[1,5-a]azepinium picrates, were synthesized from bicyclic azo compounds and nitriles in the presence of antimony pentachloride or aluminum chloride. The crystal diffraction analysis of an example product is reported and confirms the structure.

    References

  • 1 Cho H. Murakami K. Nakanishi H. Fujisawa AK. Isoshima H. Niwa M. Hayakawa K. Hase Y. Uchida I. Watanabe H. Wakitani K. Aisaka K. J. Med. Chem.  2004,  47:  101 
  • 2 Cho H, and Wakitani K. inventors; PCT Int. Appl. WO  9717349.  ; Chem. Abstr. 1997, 127, 5023
  • 3 Cho H. Murakami K. Nakanishi H. Isoshima H. Hayakawa K. Uchida I. Heterocycles  1998,  48:  919 
  • 4 Janssens FE, Lacrampe JFA, and Pilatte INC. inventors; PCT Int. Appl. WO  9413681.  ; Chem. Abstr. 1994, 121, 205360
  • 5 Cortes EC. Romero EC. Taylor AD. Garcia MCL. Trends Heterocycl. Chem.  1995,  4:  25 ; Chem. Abstr. 1997, 126, 104045
  • 6 Martinez LR. Zarraga JGA. Duran ME. Apam MTR. Canas R. Bioorg. Med. Chem. Lett.  2002,  12:  1675 
  • 7 Liu X. Wang Q. Liu Y. Fan Y. Zing Z. Synthesis  2000,  435 
  • 8 Liu X. Liu Y. Wang Q. Zou J. Synth. Commun.  2000,  30:  119 
  • 9 Wang Q. Li Z. Yang H. Li F. Ding Z. Tao F. Synthesis  2003,  1231 
  • 10 Shiraishi M, and Fukumoto S. inventors; PCT Int. Appl. WO  9942442.  ; Chem. Abstr. 1999, 131, 720
  • 11 Lipshutz BH. Chem. Rev.  1986,  86:  795 
  • 12 Iffland DC. Salisbury L. Schaefer WR. J. Am. Chem. Soc.  1961,  83:  747 
  • 13 Wang Q. Jochims JC. Kohlbrandt S. Dahlenburg L. Al-Talib M. Hamed A. Ismail AE. Synthesis  1992,  710 
  • 14a Gstach H. Seil P. Schantl JG. Gieren A. Hubner T. Wu J. Angew. Chem.  1986,  98:  1111 
  • 14b Gstach H. Seil P. Schantl JG. Gieren A. Hubner T. Wu J. Angew. Chem., Int. Ed. Engl.  1986,  25:  1132 
  • 15 For a review with respect to oximes derived from bicyclic ketones, see: Krow GR. Tetrahedron  1981,  37:  1283 
  • 16 For a theoretical study on this rearrangement, see: Wei M. Fang D. Liu R. J. Org. Chem.  2002,  67:  7432 
  • 17 Liu X. Liu Y. Ding Z. Wang Q. Zhang C. J. Heterocycl. Chem.  2000,  37:  287 
  • 18 Mintz MJ. Walling C. Org. Synth., Coll. Vol. V  1973,  184