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Synthesis 2023; 55(18): 2999-3004
DOI: 10.1055/a-2034-9821
DOI: 10.1055/a-2034-9821
paper
Special Issue Electrochemical Organic Synthesis
Electrochemical Cross-Coupling Reactions between Arylboronic Esters and Aryllithiums Using NaBr as a Halogen Mediator
This work was supported in part by Okayama Foundation for Science and Technology, Wesco Scientific Promotion Foundation, The Sanyo Broadcasting Foundation, Electric Technology Research Foundation of Chugoku, and JSPS KAKENHI grant numbers JP22H02122 (to K.M.), JP22K05115 (to S.S.), and JP21H05214 (Digitalization-driven Transformative Organic Synthesis) (to S.S.).
Abstract
An electrochemical cross-coupling reaction between arylboronic esters and aryllithiums was developed. The presence of Br– in the electrolyte was found to be essential for the reaction. NaBr was chosen as the electrolyte for its inexpensiveness and abundance, and also acted as a halogen mediator. The reaction proceeded under mild conditions to afford biaryls.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2034-9821.
- Supporting Information
Publication History
Received: 15 December 2022
Accepted after revision: 14 February 2023
Accepted Manuscript online:
14 February 2023
Article published online:
15 March 2023
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For representative recent works, see:
For recent reviews related to halogen mediators, see: