Organocatalytic Approach to the Enantioselective Total Synthesis of (+)-Serinolamides A and B and (+)-Lacosamide

Abstract

A short and highly efficient enantioselective synthesis of (+)-serinolamide A, B and (+)-lacosamide from 3-methoxypropanal using l-proline-catalyzed α-amination, Grubbs metathesis, and acid-amine coupling as key steps is reported.

Key words

enantioselective - l-proline-catalyzed - asymmetric α-amination - serinolamide A, B and lacosamide

Publikationsverlauf

Eingereicht: 19. Oktober 2023

Angenommen nach Revision: 04. Dezember 2023

Accepted Manuscript online:
04. Dezember 2023

Artikel online veröffentlicht:
31. Januar 2024

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