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Synthesis 2013; 45(11): 1553-1563
DOI: 10.1055/s-0033-1338424
DOI: 10.1055/s-0033-1338424
paper
A Sequential One-Pot Protocol for the Synthesis of Dihydrobenzo[6,7]indolo-[3′,4′:3,4,5]azepino[2,1-a]isoquinolines Using a Gold–Silver Combined Catalyst[1]
Further Information
Publication History
Received: 12 March 2013
Accepted after revision: 26 March 2013
Publication Date:
08 May 2013 (online)
Abstract
A sequential one-pot protocol for the synthesis of indole-based peri-annulated polyheterocycles using trifluoroacetic acid and a gold–silver combined catalyst system is described. The reaction is thought to proceed via an imine formation–cationic π-cyclization–alkyne activation–intramolecular hydroamination sequence to yield novel dihydrobenzo[6,7]indolo[3′,4′:3,4,5]azepino[2,1-a]isoquinolines in good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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