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Synthesis 2013; 45(14): 2043-2050
DOI: 10.1055/s-0033-1338854
DOI: 10.1055/s-0033-1338854
paper
A Simple One-Pot Synthesis of 2-Substituted Quinazolin-4(3H)-ones from 2-Nitrobenzamides by Using Sodium Dithionite
Further Information
Publication History
Received: 29 January 2013
Accepted after revision: 19 April 2013
Publication Date:
14 June 2013 (online)
Abstract
A simple one-pot procedure for the preparation of 2-(het)arylquinazolin-4(3H)-ones starting from readily available 2-nitrobenzamides and (het)aryl aldehydes is described. Sodium dithionite is used as the reducing agent for the nitro group, and its decomposition in situ in aqueous N,N-dimethylformamide leads to the final oxidation step that gives the desired heterocyclic compounds.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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