An Efficient One-Pot Strategy for the Synthesis of Triazole-Fused 1,4-Benzodiazepinones from N-Substituted 2-Azidobenzamides

Abstract

A catalyst-free, one-pot strategy for the synthesis of 1,2,3-triazole-fused 1,4-benzodiazepinone derivatives from N-substituted 2-azidobenzamides and propargyl bromide, in the presence of a base, is reported. The products are formed in good to excellent yields via N-alkylation followed by a 1,3-dipolar cycloaddition.

Key words

fused triazole - azide–alkyne cycloaddition - 1,4-benzodiazepinones - N-substituted 2-azidobenzamides - catalyst-free

• References

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For earlier examples of the syntheses of heterocycles from our group, see:
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