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Synthesis 2001; 2001(3): 0478-0482
DOI: 10.1055/s-2001-11449
DOI: 10.1055/s-2001-11449
paper
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Efficient Synthesis of N-3-Substituted 6-Aminouracil Derivatives via N 6-[(Dimethylamino)methylene] Protection
Further Information
Publication History
Publication Date:
31 December 2001 (online)
A convenient synthetic procedure has been developed to introduce different functional groups at position 3 of 6-amino-1-benzyl- or 6-amino-1-methyluracil based on N 6-[(dimethylamino)methylene] protection. This method allows for the smooth substitution at N-3 even when base-labile or heat sensitive halide reagents are employed.
alkylations - heterocycles - protecting groups - nucleobases