Antinociceptive and Anti-Inflammatory Steroidal Saponins from Dracaena ombet

Abstract

Two new steroidal saponins, namely (25R)-5β-spirostan-3-β-ol 3-O-β-D-galactopyranosyl-(1″′→4′′)-O-β-D-galactopyranosyl-(1″→3′)-O-β-D-glucopyranoside (2), and (25R)-5β-spirostan-3-β-ol 3-O-β-D-galactopyranosyl-(1″′→4′′)-O-β-D-glucopyranosyl-(1″→3′)-O-β-D-glucopyranoside (3), together with six known constituents, have been isolated from the leaves of Dracaena ombet Kotschy & Peyr. (Dracaenaceae). The structures of the two saponins were established by chemical and physicochemical analyses, including FAB- and HR-ESI-MS and 2D NMR. The fraction rich in saponins showed significant analgesic and anti-inflammatory activities (at a high dose of 30 mg/kg b. w.) and non-significant antiulcer activities at the same doses.

Key words

Dracaena ombet - Dracaenaceae - smilagenin glycosides - sulphated triterpenoidal saponin - flavonoids - analgesic - anti-inflammatory - antiulcer

References

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