Die Limbokeratoplastik zur Behandlung von gittrigen und granulären Hornhautdystrophien

Zusammenfassung

Die homologe Limbokeratoplastik (Limbo-KP) wurde initial zur Behandlung von Formen schwerer Limbusinsuffizienz etabliert, um nach Transplantation einen vollständigen und dauerhaften Epithelschluss im Bereich der Hornhaut zu gewährleisten. Nach Erweiterung des Indikationsspektrums kommt die Limbo-KP mittlerweile auch bei epithelialen/stromalen Hornhautdystrophien wie der gittrigen und der granulären Hornhautdystrophie (die mit einer Mutation im TGFBI-Gen [TGFBI: transforming growth factor beta-induced] assoziiert sind) zum Einsatz. Ziel der Limbo-KP hierbei ist es, ein klares Transplantatüberleben ohne Rezidiv der Dystrophie im Transplantat zu erreichen, da es nach konventioneller Keratoplastik stets zu Rezidiven und einer damit einhergehenden Visusminderung kommt.

Abstract

The surgical technique of limbokeratoplasty (limbo-KP) was initially established for the treatment of severe limbal deficiencies. Besides improving visual acuity, surgery is aimed at ensuring complete, long-lasting epithelialization of the ocular surface. Due to the extension of the indication spectrum, limbo-KPs are also used in various forms of epithelial/stromal corneal dystrophies such as lattice and granular (transforming growth factor beta-induced [TGFBI] gene mutation associated) dystrophies. The objective of limbo-KP is to ensure prolonged clear graft survival without a recurrence of the dystrophy as otherwise observed after conventional keratoplasty.

Schlüsselwörter

Limbokeratoplastik - Keratoplastik - Hornhautdystrophie - Transplantatüberleben - Hornhauttransplantatabstoßung

Key words

limbokeratoplasty - keratoplasty - corneal dystrophy - corneal graft survival - corneal graft rejection

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