Modified Fe₃O₄/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study

Abstract

The adsorption capacity and release attributes of magnetic Fe₃O₄@hydroxyapatite (Fe₃O₄/HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe₃O₄@hydroxyapatite and functionalized Fe₃O₄@hydroxyapatite) were then conducted. The characteristic of the obtained materials was performed with X-ray-diffraction (XRD), energy dispersive X-ray microanalysis (EDS), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-Vis analysis, vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). Results show that functionalized magnetic Fe₃O₄@hydroxyapatite nanoparticles leads than a substantial decrease of the drug delivery rate in pH=6.8 after investigated drug release in intestine environment. In addition, the results demonstrate that high adsorption capacity for drug and slower drug release rate was obtained after functionalized nanoparticles than Fe₃O₄@hydroxyapatite and pure hydroxyapatite.

Key word

Drug delivery - Ibuprofen - APTS - Hydroxyapatite - Scanning electron microscopy

• References

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