Drug Res (Stuttg) 2020; 70(01): 6-11
DOI: 10.1055/a-0991-7585
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

Elham Ahmadian
1  Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2  Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3  Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
,
Solmaz Maleki Dizaj
1  Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
,
Aziz Eftekhari
4  Maragheh University of Medical Sciences, Maragheh, Iran
,
Elaheh Dalir
5  Research Center for Pharmaceutical Nanotechnology, Biomedicine Institue, Tabriz University of Medical Sciences, Tabriz, Iran
,
Parviz Vahedi
4  Maragheh University of Medical Sciences, Maragheh, Iran
,
Amir Hasanzadeh
4  Maragheh University of Medical Sciences, Maragheh, Iran
,
Mohammad Samiei
6  Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
› Author Affiliations
Further Information

Publication History

received 12 May 2019

accepted 05 August 2019

Publication Date:
25 September 2019 (online)

Abstract

Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.