Drug Res (Stuttg) 2020; 70(02/03): 97-100
DOI: 10.1055/a-1070-9052
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Development of the Composition of the Biopolymer Base for Nasal Gel

Elena Bakhrushina
1  Department of Pharmaceutical Technology, I M Sechenov First Moscow State Medical University, Moskva, Russian Federation
,
Natalya Demina
1  Department of Pharmaceutical Technology, I M Sechenov First Moscow State Medical University, Moskva, Russian Federation
,
Ivan Krasnyuk
1  Department of Pharmaceutical Technology, I M Sechenov First Moscow State Medical University, Moskva, Russian Federation
,
Anna Moiseeva
1  Department of Pharmaceutical Technology, I M Sechenov First Moscow State Medical University, Moskva, Russian Federation
› Author Affiliations
Further Information

Publication History

received 23 October 2019

accepted 18 November 2019

Publication Date:
22 January 2020 (online)

Abstract

In many cases the nasal cavity is the gateway for the infection; it necessitates the development of a drug for nasal administration with antiviral, adsorptive and protective properties. Gels were chosen as an optimal dosage form. The study is aimed at studying the properties of biopolymer gelling agents and determining the composition of the future dosage form.

Materials and methods Gel samples with 3, 4 and 5% concentrations were prepared using the following gelling agents: sodium alginate Protanal CR8223, Protanal CR8133, Manucol LKХ (FMC BioPolymer) and xanthan gum GrinstedXanthan (DuPontDanisco), Xanthural 180 (CP Kelco). Adsorption and osmotic activity, bioadhesion and thermostability of the samples were determined.

Results Basing on the totality of the obtained results, 3 compositions prospective for the dosage form development were selected: xanthan gums (particle size 180pm) from various manufacturers: Grinsted Xanthan 3 and 4% concentrations, Xanthural 180 5% concentration. These compositions possess high adsorption activity (25.06; 21.35; 20.6 g respectively), optimal osmotic activity (155, 171, 100%) and have significant bioadhesion (28.4421; 22.7237; 30.2835 N) that allows the drug to stay in the nasal cavity for a long period of time. All selected compositions demonstrated good high-temperature stability.

Conclusion The obtained data shows prospects of applying the samples for the development of nasal gel with an immunobiological substance.