Abstract
In many cases the nasal cavity is the gateway for the infection; it necessitates the
development of a drug for nasal administration with antiviral, adsorptive and protective
properties. Gels were chosen as an optimal dosage form. The study is aimed at studying
the properties of biopolymer gelling agents and determining the composition of the
future dosage form.
Materials and methods Gel samples with 3, 4 and 5% concentrations were prepared using the following gelling
agents: sodium alginate Protanal CR8223, Protanal CR8133, Manucol LKХ (FMC BioPolymer)
and xanthan gum GrinstedXanthan (DuPontDanisco), Xanthural 180 (CP Kelco). Adsorption
and osmotic activity, bioadhesion and thermostability of the samples were determined.
Results Basing on the totality of the obtained results, 3 compositions prospective for the
dosage form development were selected: xanthan gums (particle size 180pm) from various
manufacturers: Grinsted Xanthan 3 and 4% concentrations, Xanthural 180 5% concentration.
These compositions possess high adsorption activity (25.06; 21.35; 20.6 g respectively),
optimal osmotic activity (155, 171, 100%) and have significant bioadhesion (28.4421;
22.7237; 30.2835 N) that allows the drug to stay in the nasal cavity for a long period
of time. All selected compositions demonstrated good high-temperature stability.
Conclusion The obtained data shows prospects of applying the samples for the development of
nasal gel with an immunobiological substance.
Keywords
pulmonary & respiratory pharmacology - antiviral drugs - drug research
