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Drug Res (Stuttg) 2021; 71(03): 149-156
DOI: 10.1055/a-1296-7751
Original Article

Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids

Pinki Yadav
1   Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
,
Kashmiri Lal
1   Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
,
Ashwani Kumar
2   Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
› Author Affiliations Funding: This work was carried out under the financial support from Haryana State Council for Science & Technology (HSCST) in the form of Junior Research Fellowship (Pinki Yadav) and PURSE program No. SR/PURSE 2/40(G) from DST, New Delhi.
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Abstract

The in vitro antimicrobial properties of some chalcones (1a–1c ) and chalcone tethred 1,4-disubstituted 1,2,3-triazoles (2a–2u) towards different microbial strains viz. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans are reported. Compounds 2g and 2u exhibited better potency than the standard Fluconazole with MIC values of 0.0063 µmol/mL and 0.0068 µmol/mL, respectively. Furthermore, molecular docking was performed to investigate the binding modes of two potent compounds 2q and 2g with E. coli topoisomerase II DNA gyrase B and C. albicans lanosterol 14α-demethylase, respectively. Based on these results, a statistically significant quantitative structure activity relationship (QSAR) model was successfully summarized for antibacterial activity against B. subtilis.

Key words

1,4-Disubstituted 1,2,3-triazoles - Chalcones - antimicrobial activity - docking simulation


Publication History

Received: 13 August 2020

Accepted: 19 October 2020

Article published online:
07 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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