Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids

Pinki Yadav; Kashmiri Lal; Ashwani Kumar

doi:10.1055/a-1296-7751

Drug Research, Table of Contents

Drug Res (Stuttg) 2021; 71(03): 149-156
DOI: 10.1055/a-1296-7751

Original Article

Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids

Pinki Yadav

¹Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

,

Kashmiri Lal

¹Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

,

Ashwani Kumar

²Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

› Author Affiliations

Abstract

The in vitro antimicrobial properties of some chalcones (1a–1c ) and chalcone tethred 1,4-disubstituted 1,2,3-triazoles (2a–2u) towards different microbial strains viz. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans are reported. Compounds 2g and 2u exhibited better potency than the standard Fluconazole with MIC values of 0.0063 µmol/mL and 0.0068 µmol/mL, respectively. Furthermore, molecular docking was performed to investigate the binding modes of two potent compounds 2q and 2g with E. coli topoisomerase II DNA gyrase B and C. albicans lanosterol 14α-demethylase, respectively. Based on these results, a statistically significant quantitative structure activity relationship (QSAR) model was successfully summarized for antibacterial activity against B. subtilis.

Key words

1,4-Disubstituted 1,2,3-triazoles - Chalcones - antimicrobial activity - docking simulation

Full Text

References

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