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CC BY-NC-ND 4.0 · SynOpen 2022; 06(03): 158-163
DOI: 10.1055/a-1843-6641
DOI: 10.1055/a-1843-6641
paper
The Synthesis of 5-Hydroxybenzofurans via Tandem In Situ Oxidative Coupling and Cyclization
We gratefully acknowledge financial support from the National Natural Science Foundation of China (20972051 and 21476078, X.-H.Y.) and the Science and Technology Commission of Shanghai Municipality (No. 12431900902, X.-H. Y.).
Abstract
A series of 5-hydroxybenzofurans have been prepared by PIDA-mediated oxidation and coupling cyclization of β-dicarbonyl compounds and hydroquinones. The reaction functionalizes C(sp2)–H of hydroquinones directly with yields of target molecules up to 96%.
Key words
5-hydroxybenzofurans - oxidation - dearomatization - aromatic C(sp2)–H functionalization - one-pot reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1843-6641.
- Supporting Information
Publikationsverlauf
Eingereicht: 28. Februar 2022
Angenommen nach Revision: 27. April 2022
Accepted Manuscript online:
04. Mai 2022
Artikel online veröffentlicht:
19. Juli 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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For recent reviews, see:
Selected recent reviews, see:
Enantioselective [3+2] cycloaddition: