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DOI: 10.1055/a-1970-3664
Indikationsstellung in der Adipositastherapie – Surgeons first? // Indications in obesity therapy - surgeons first?
Indications in Obesity Therapy - Surgeons First?
Zusammenfassung
Die Adipositas ist weltweit ein zunehmendes Problem. Seit dem Jahr 2010 waren erstmals mehr Menschen übergewichtig als untergewichtig. Insbesondere die adipositasassoziierten Erkrankungen, allen voran der Diabetes mellitus Typ II, stellen das Gesundheitssystem vor enorme Herausforderungen. Am 3. Juli 2020 hat der Deutsche Bundestag Adipositas als Krankheit anerkannt und die Entwicklung eines Disease-Management-Programms (DMP) angestoßen, das zurzeit ausgearbeitet wird. Bisher richtet sich die Indikation einer Behandlung der Adipositas in Deutschland nach der S3-Leitlinie „Chirurgie der Adipositas und metabolischer Erkrankungen“ der DGAV von 2018 und der S3-Leitlinie „Prävention und Therapie der Adipositas“ der Deutschen Adipositas-Gesellschaft e. V. von 2014. Dieser Artikel gibt einen Überblick über die aktuell in Deutschland verfügbaren konservativen, medikamentösen, endoskopischen und chirurgischen Therapiemethoden des Übergewichts und der Adipositas und erläutert die Indikationen. Vor dem Hintergrund der Neuausrichtung der Adipositasbehandlung im Rahmen des DMP und der anstehenden Überarbeitungen der Leitlinien sollte die bisherige Indikationsstellung kritisch diskutiert werden. Die wissenschaftlichen Erkenntnisse der letzten Jahre zeigen, dass durch eine chirurgische Behandlung der Adipositas aktuell im Langzeitverlauf nicht nur der größte Gewichtsverlust erreicht wird, sondern auch, dass adipositasassoziierte Erkrankungen effektiver behandelt werden und die Gesamtmortalität im Vergleich zur konservativen Behandlung deutlich effektiver gesenkt wird.
Abstract
Obesity is a growing problem worldwide. For the first time since 2010, more people have been overweight than underweight. In particular, obesity-associated diseases, above all type 2 diabetes mellitus, pose enormous challenges to the healthcare system. On July 3, 2020, the German Bundestag recognised obesity as a disease and initiated the development of a diseases management program (DMP), which is currently being drawn up. So far, the indication for treatment of obesity in Germany has been based on the S3 guideline “Surgery of obesity and metabolic diseases” of the DGAV from 2018 and the S3 guideline “Prevention and therapy of obesity” of the German Obesity Society e. V. from 2014. This article gives an overview of the currently available conservative, medical, endoscopic and surgical treatment methods for overweight and obesity in Germany and explains the indications. Against the background of the reorientation of obesity treatment as a part of the DMP and the forthcoming revisions of the guidelines, the previous indication should be discussed critically. The scientific findings of the last few years show that surgical treatment of obesity not only achieves the greatest weight loss in the long term, but also that obesity-associated diseases are then treated more effectively and overall mortality is reduced significantly more effectively than with conservative treatment.
Schlüsselwörter
Adipositas - Adipositastherapie - Adipositaschirurgie - Indikationsstellung - LeitlinienPublication History
Received: 01 August 2022
Accepted after revision: 26 October 2022
Article published online:
07 December 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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Literatur
- 1 World Health Organization. WHO European Regional Obesity Report 2022. Accessed November 08, 2022 at: https://www.who.int/europe/publications/i/item/9789289057738
- 2 Damerow S, Rommel A, Prütz F. et al. Gesundheitliche Lage der Bevölkerung zu Beginn der COVID-19-Pandemie. J Health Monitor 2020; DOI: 10.25646/7171.2.
- 3 Kivimäki M, Strandberg T, Pentti J. et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study. Lancet Diabetes Endocrinol 2022; 10: 253-263 DOI: 10.1016/S2213-8587(22)00033-X. (PMID: 35248171)
- 4 Younossi ZM, Stepanova M, Younossi Y. et al. Epidemiology of chronic liver diseases in the USA in the past three decades. Gut 2019; 69: 564-568 DOI: 10.1136/gutjnl-2019-318813. (PMID: 31366455)
- 5 Madlock-Brown CR, Reynolds RB, Bailey JE. Increases in multimorbidity with weight class in the United States. Clin Obes 2021; 11: e12436 DOI: 10.1111/cob.12436. (PMID: 33372406)
- 6 Hazelwood E, Sanderson E, Tan VY. et al. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis. BMC Med 2022; 20: 125 DOI: 10.1186/s12916-022-02322-3. (PMID: 35436960)
- 7 Andreyeva T, Sturm R, Ringel JS. Moderate and severe obesity have large differences in health care costs. Obes Res 2004; 12: 1936-1943 DOI: 10.1038/oby.2004.243. (PMID: 15687394)
- 8 International Diabetes Federation (IDF). IDF Diabetes Atlas 2021. 10th edition. Brussels: Accessed November 08, 2022 at: https://diabetesatlas.org/atlas/tenth-edition/
- 9 Gloy VL, Briel M, Bhatt DL. et al. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 347: f5934 DOI: 10.1136/bmj.f5934. (PMID: 24149519)
- 10 Fink J, Seifert G, Blüher M. et al. Obesity surgery—weight loss, metabolic changes, oncological effects, and follow-up. Dtsch Arztebl Int 2022; 119: 70-80 DOI: 10.3238/arztebl.m2021.0359. (PMID: 34819222)
- 11 Stroh C. Bariatrische Chirurgie: Magenbypass bevorzugte Operation. Dtsch Arztebl 2016; 113: A 980-A 982
- 12 Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV). S3-Leitlinie: Chirurgie der Adipositas und metabolischer Erkrankungen. Version 2.3 (Februar 2018). AWMF-Register-Nr. 088/001. Accessed November 08, 2022 at: https://www.awmf.org/uploads/tx_szleitlinien/088–001l_S3_Chirurgie-Adipositas-metabolische-Erkrankugen_2018–02.pdf
- 13 Deutsche Adipositas Gesellschaft (DAG). S3-Leitlinie: Prävention und Therapie der Adipositas. Version 2.0 (April 2014). AWMF-Register-Nr. 050/001. Accessed November 08, 2022 at: https://www.awmf.org/uploads/tx_szleitlinien/050–001l_S3_Adipositas_Pr%C3%A4vention_Therapie_2014–11-abgelaufen.pdf
- 14 Wirth A, Wabitsch M, Hauner H. The prevention and treatment of obesity. Dtsch Arztebl Int 2014; 111: 705-713 DOI: 10.3238/arztebl.2014.0705. (PMID: 25385482)
- 15 Angrisani L, Santonicola A, Iovino P. et al. Bariatric Surgery Survey 2018: Similarities and Disparities Among the 5 IFSO Chapters. Obes Surg 2021; 31: 1937-1948 DOI: 10.1007/s11695-020-05207-7. (PMID: 33432483)
- 16 Arterburn D, Wellman R, Emiliano A. et al. Comparative effectiveness and safety of bariatric procedures for weight loss: a PCORnet cohort study. Ann Intern Med 2018; 169: 741-750 DOI: 10.7326/M17-2786. (PMID: 30383139)
- 17 Sharples A, Mahawar K. Systematic Review and Meta-Analysis of Randomised Controlled Trials Comparing Long-Term Outcomes of Roux-En-Y Gastric Bypass and Sleeve Gastrectomy. Obes Surg 2020; 30: 664-672 DOI: 10.1007/s11695-019-04235-2. (PMID: 31724116)
- 18 O’Brien PE, Hindle A, Brennan L. et al. Long-term outcomes after bariatric surgery: a systematic review and meta-analysis of weight loss at 10 or more years for all bariatric procedures and a single-centre review of 20-year outcomes after adjustable gastric banding. Obes Surg 2019; 29: 3-14 DOI: 10.1007/s11695-018-3525-0. (PMID: 30293134)
- 19 Rheinwalt KP, Plamper A, Rückbeil MV. et al. One Anastomosis Gastric Bypass-Mini-Gastric Bypass (OAGB-MGB) Versus Roux-en-Y Gastric Bypass (RYGB)-a Mid-Term Cohort Study with 612 Patients. Obes Surg 2020; 30: 1230-1240 DOI: 10.1007/s11695-019-04250-3. (PMID: 31758474)
- 20 Robert M, Espalieu P, Pelascini E. et al. Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial. Lancet 2019; 393: 1299-1309 DOI: 10.1016/S0140-6736(19)30475-1. (PMID: 30851879)
- 21 Taheri S, Zaghloul H, Chagoury O. et al. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. Lancet Diabetes Endocrinol 2020; 8: 477-489 DOI: 10.1016/S2213-8587(20)30117-0. (PMID: 32445735)
- 22 Wing RR, Bolin P, Brancati FL. et al. Look AHEAD Research Group; Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013; 369: 145-154 DOI: 10.1177/19386400221124199. (PMID: 36112801)
- 23 Simonson DC, Halperin F, Foster K. et al. Clinical and patient-centered outcomes in obese patients with type 2 diabetes 3 years after randomization to Roux-en-Y gastric bypass surgery versus intensive lifestyle management: the SLIMM-T2D Study. Diabetes Care 2018; 41: 670-679 DOI: 10.2337/dc17-0487. (PMID: 29432125)
- 24 Schauer PR, Bhatt DL, Kirwan JP. STAMPEDE Investigators. et al. Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. N Engl J Med 2017; 376: 641-651 DOI: 10.1097/SLA.0000000000005003. (PMID: 34132694)
- 25 Mingrone G, Panunzi S, De Gaetano A. et al. Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial. Lancet 2015; 386: 964-973 DOI: 10.1016/S0140-6736(15)00075-6. (PMID: 26369473)
- 26 Maciejewski ML, Arterburn DE, Van Scoyoc L. et al. Bariatric surgery and long-term durability of weight loss. JAMA Surg 2016; 151: 1046-1055 DOI: 10.1001/jamasurg.2016.2317. (PMID: 27579793)
- 27 Adams TD, Davidson LE, Litwin SE. et al. Weight and Metabolic outcomes 12 years after gastric bypass. N Engl J Med 2017; 377: 1143-1155 DOI: 10.1056/NEJMoa1700459. (PMID: 28930514)
- 28 Arterburn DE, Telem DA, Kushner RF. Benefits and Risks of Bariatric Surgery in Adults: A Review. JAMA 2020; 324: 879-887 DOI: 10.1001/jama.2020.12567. (PMID: 32870301)
- 29 Aminian A, Brethauer SA, Andalib A. et al. Individualized metabolic surgery score: procedure selection based on diabetes severity. Ann Surg 2017; 266: 650-657 DOI: 10.1097/SLA.0000000000002407. (PMID: 28742680)
- 30 Lassailly G, Caiazzo R, Ntandja-Wandji LC. et al. Bariatric surgery provides long-term resolution of nonalcoholic steatohepatitis and regression of fibrosis. Gastroenterology 2020; 159: 1290-1301.e5 DOI: 10.1053/j.gastro.2020.06.006. (PMID: 32553765)
- 31 Nickel F, Tapking C, Benner L. et al. Bariatric Surgery as an Efficient Treatment for Non-Alcoholic Fatty Liver Disease in a Prospective Study with 1-Year Follow-up. Obes Surg 2018; 28: 1342-1350 DOI: 10.1007/s11695-017-3012-z. (PMID: 29119336)
- 32 Lassailly G, Caiazzo R, Buob D. et al. Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients. Clin Gastroenterol 2015; 149: 379-388
- 33 Alsumali A, Al-Hawag A, Bairdain S. et al. The impact of bariatric surgery on pulmonary function: a meta-analysis. Surg Obes Relat Dis 2018; 14: 225-236 DOI: 10.1016/j.soard.2017.09.533. (PMID: 29126864)
- 34 Peters U, Hernandez P, Dechman G. et al. Early detection of changes in lung mechanics with oscillometry following bariatric surgery in severe obesity. Appl Physiol Nutr Metab 2016; 41: 538-547 DOI: 10.1139/apnm-2015-0473. (PMID: 27109263)
- 35 Schiavon CA, Bhatt DL, Ikeoka D. et al. Three-Year Outcomes of Bariatric Surgery in Patients With Obesity and Hypertension: A Randomized Clinical Trial. Ann Intern Med 2020; 173: 685-693 DOI: 10.7326/M19-3781. (PMID: 32805133)
- 36 Hung S, Chen C, Chin W. et al. The long-term risk of cardiovascular events in patients following bariatric surgery compared to a non-surgical population with obesity and the general population: a comprehensive national cohort study. Langenbecks Arch Surg 2021; 406: 189-196 DOI: 10.1007/s00423-020-02027-2. (PMID: 33174167)
- 37 Carlsson L, Sjöholm K, Jacobson P. et al. Life expectancy after bariatric surgery in the Swedish Obese Subject Study. N Engl J Med 2020; 383: 1535 DOI: 10.1056/NEJMoa2002449. (PMID: 33053284)
- 38 Syn NL, Cummins DE, Wang LZ. et al. Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174772 participants. Lancet 2021; 397: 1830-1841
- 39 [Anonym]. Adipositas EMA fordert Verbot des Anorektikums Amfepramon. Accessed November 08, 2022 at: https://www.aerzteblatt.de/nachrichten/135035/Adipositas-EMA-fordert-Verbot-des-Anorektikums-Amfepramon
- 40 Lucchetta RC, Riveros BS, Pontarolo R. et al. Systematic review and meta-analysis of the efficacy and safety of amfepramone and mazindol as a monotherapy for the treatment of obese or overweight patients. Clinics (Sao Paulo) 2017; 72: 317-324 DOI: 10.6061/clinics/2017(05)10. (PMID: 28591345)
- 41 Greenway FL, Fujioka K, Plodkowski RA. et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2010; 376: 595-605 DOI: 10.1016/S0140-6736(10)60888-4. (PMID: 20673995)
- 42 Torgerson JS, Hauptman J, Boldrin MN. et al. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004; 27: 155-161 DOI: 10.2337/diacare.27.1.155. (PMID: 14693982)
- 43 Pi-Sunyer X, Astrup A, Fujioka K. et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med 2015; 373: 11-22 DOI: 10.1056/NEJMoa1411892. (PMID: 26132939)
- 44 Le Roux CW, Astrup A, Fujioka K. et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet 2017; 389: 1399-1409 DOI: 10.1016/S0140-6736(17)30069-7. (PMID: 28237263)
- 45 Wilding JPH, Batterham RL, Calanna S. et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med 2021; 384: 989-1002 DOI: 10.1056/NEJMoa2032183. (PMID: 33567185)
- 46 Keller U, Gerber PP, Stauffacher W. Stimulatory effect of norepinephrine on ketogenesis in normal and insulin-deficient humans. Am J Physiol 1984; 247: E732-E739 DOI: 10.1152/ajpendo.1984.247.6.E732. (PMID: 6150642)
- 47 Hollander P, Gupta AK, Plodkowski R. et al. Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes. Diabetes Care 2013; 36: 4022-4029 DOI: 10.2337/dc13-0234. (PMID: 24144653)
- 48 Jeon WS, Park CY. Antiobesity pharmacotherapy for patients with type 2 diabetes: focus on long-term management. Endocrinol Metab (Seoul) 2014; 29: 410-417 DOI: 10.3803/EnM.2014.29.4.410. (PMID: 25559569)
- 49 Marso SP, Daniels GH, Brown-Frandsen K. et al. LEADER Steering Committee. LEADER Trial Investigators Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016; 375: 311-322
- 50 Iqbal J, Wu HX, Hu N. et al. Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus-a systematic review and meta-analysis of randomized control trials. Obes Rev 2022; 23: e13435 DOI: 10.1111/obr.13435. (PMID: 35194917)
- 51 Sklyanik IA, Shestakova EA, Yurasov AV. et al. [Glycemia normalization in patients with obesity and type 2 diabetes mellitus: bariatric surgery vs pharmacological therapy]. Ter Arkh 2019; 91: 34-38 DOI: 10.26442/00403660.2019.10.000375. (PMID: 32598629)
- 52 Merlotti C, Morabito A, Pontiroli AE. Prevention of type 2 diabetes; a systematic review and meta-analysis of different intervention strategies. Diabetes Obes Metab 2014; 16: 719-727 DOI: 10.1016/j.jbmt.2021.10.003. (PMID: 35248261)
- 53 Abu Dayyeh B, Kumar N, Edmundowicz S. ASGE Bariatric Endoscopy Task Force, ASGE Technology Committee. et al. ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies. Gastrointest Endosc 2015; 82: 425-438.e5 DOI: 10.1016/j.gie.2015.03.1964. (PMID: 26232362)
- 54 Neto MG, Silva LB, Grecco E. et al. Brazilian intragastric balloon consensus statement (BIBC): practical guidelines based on experience of over 40 000 cases. Surg Obes Relat Dis 2018; 14: 151-159 DOI: 10.1016/j.soard.2017.09.528. (PMID: 29108896)
- 55 Tate CM, Geliebter A. Intragastric Balloon Treatment for Obesity: Review of Recent Studies. Adv Ther 2017; 34: 1859-1875 DOI: 10.1007/s12325-017-0562-3. (PMID: 28707286)
- 56 Leeman MF, Ward C, Duxbury M. et al. The intra-gastric balloon for preoperative weight loss in bariatric surgery: is it worthwhile?. Obes Surg 2013; 23: 1262-1265 DOI: 10.1007/s11695-013-0896-0. (PMID: 23460262)
- 57 Banks J, Abouelazayem M, Kaur V. Routine Intra-gastric Balloon Insertion in the Management of ‘Super-Super-Obese’ Patients: an Obituary?. Obes Surg 2021; 31: 2319-2323 DOI: 10.1007/s11695-020-05102-1. (PMID: 33151519)
- 58 Kumar N, Abu Dayyeh BK, Lopez-Nava Breviere G. et al. Endoscopic sutured gastroplasty: procedure evolution from first-in-man cases through current technique. Surg Endosc 2018; 32: 2159-2164 DOI: 10.1007/s00464-017-5869-2. (PMID: 29075966)
- 59 Alqahtani A, Al-Darwish A, Mahmoud A. et al. Short-term outcomes of endoscopic sleeve gastroplasty in 1000 consecutive patients. Gastrointest Endosc 2019; 89: 1132-1138 DOI: 10.1016/j.gie.2018.12.012. (PMID: 30578757)
- 60 Sartoretto A, Sui Z, Hill C. et al. Endoscopic sleeve gastroplasty (ESG) is a reproducible and effective endoscopic bariatric therapy suitable for widespread clinical adoption: a large, international multicenter study. Obes Surg 2018; 28: 1812-1821 DOI: 10.1007/s11695-018-3135-x. (PMID: 29450845)
- 61 Ruban A, Ashrafian H, Teare JP. et al. The EndoBarrier: Duodenal-Jejunal Bypass Liner for Diabetes and Weight Loss. Gastroenterol Res Pract 2018; 2018: 7823182 DOI: 10.1155/2018/7823182. (PMID: 30147720)
- 62 Fiorillo C, Quero G, Vix M. et al. 6-month gastrointestinal quality of life (QoL) results after endoscopic sleeve gastroplasty and laparoscopic sleeve gastrectomy: a propensity score analysis. Obes Surg 2020; 30: 1944-1951 DOI: 10.1007/s11695-020-04419-1. (PMID: 31965488)
- 63 Daigle CR, Brethauer SA, Tu C. et al. Which postoperative complications matter most after bariatric surgery? Prioritizing quality improvement efforts to improve national outcomes. Surg Obes Relat Dis 2018; 14: 652-657 DOI: 10.1016/j.soard.2018.01.008. (PMID: 29503096)
- 64 Aminian A, Brethauer SA, Kirwan JP. et al. How safe is metabolic/diabetes surgery?. Diabetes Obes Metab 2015; 17: 198-201 DOI: 10.1111/dom.12405. (PMID: 25352176)
- 65 Matrana MR, Davis WE. Vitamin deficiency after gastric bypass surgery: a review. South Med J 2009; 102: 1025 DOI: 10.1097/SMJ.0b013e3181b62614. (PMID: 19738526)
- 66 Paccou J, Caiazzo R, Lespessailles E. et al. Bariatric Surgery and Osteoporosis. Calcif Tissue Int 2022; 110: 576-591 DOI: 10.1007/s00223-020-00798-w. (PMID: 33403429)
- 67 Howard R, Yang J, Thumma J. et al. Long-term comparative effectiveness of gastric bypass and sleeve gastrectomy on use of antireflux medication: a difference-in-differences analysis. Surg Obes Relat Dis 2022; 18: 1033-1041 DOI: 10.1016/j.soard.2022.04.016. (PMID: 35649735)
- 68 Yeung KTD, Penney N, Ashrafian L. et al. Does sleeve gastrectomy expose the distal esophagus to severe reflux? A systematic review and meta-analysis. Ann Surg 2020; 271: 257-265 DOI: 10.1097/SLA.0000000000003275. (PMID: 30921053)
- 69 Leslie D, Wise E, Sheka A. et al. Gastroesophageal Reflux Disease Outcomes After Vertical Sleeve Gastrectomy and Gastric Bypass. Ann Surg 2021; 274: 646-653 DOI: 10.1097/SLA.0000000000005061. (PMID: 34506320)
- 70 Salminen P, Grönroos S, Helmiö M. et al. Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial. JAMA Surg 2022; 157: 656-666 DOI: 10.1001/jamasurg.2022.2229. (PMID: 35731535)
- 71 Grönroos S, Helmiö M, Juuti A. et al. Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss and Quality of Life at 7 Years in Patients With Morbid Obesity. The SLEEVEPASS Randomized Clinical Trial. JAMA Surg 2021; 156: 137-146 DOI: 10.1001/jamasurg.2020.5666. (PMID: 33295955)
- 72 Carandina S, Soprani A, Zulian V. et al. Long-Term Results of One Anastomosis Gastric Bypass: a Single Center Experience with a Minimum Follow-Up of 10 Years. Obes Surg 2021; 31: 3468-3475 DOI: 10.1007/s11695-021-05455-1. (PMID: 34097238)
- 73 Garvey WT, Mechanick JI. Proposal for a scientifically correct and medically actionable disease classification system (ICD) for obesity. Obesity (Silver Spring) 2020; 28: 484-492 DOI: 10.1002/oby.22727. (PMID: 32090513)
- 74 Panunzi S, De Gaetano A, Carnicelli A. et al. Predictors of remission of diabetes mellitus in severely obese individuals undergoing bariatric surgery: do BMI or procedure choice matter? A meta-analysis. Ann Surg 2015; 261: 459-467 DOI: 10.1097/SLA.0000000000000863. (PMID: 25361217)
- 75 Müller-Stich BP, Senft JD, Warschkow R. et al. Surgical versus medical treatment of type 2 diabetes mellitus in nonseverely obese patients: a systematic review and meta-analysis. Ann Surg 2015; 261: 421-429 DOI: 10.1097/SLA.0000000000001014. (PMID: 25405560)
- 76 Stenberg E, Bruze G, Sundström J. et al. Comparison of Sleeve Gastrectomy vs Intensive Lifestyle Modification in Patients With a BMI of 30 to Less Than 35. JAMA Netw Open 2022; 5: e2223927 DOI: 10.1001/jamanetworkopen.2022.23927. (PMID: 35895057)
- 77 Billeter AT, Scheurlen KM, Probst P. et al. Meta-analysis of metabolic surgery versus medical treatment for microvascular complications in patients with type 2 diabetes mellitus. Br J Surg 2018; 105: 168-181 DOI: 10.1002/bjs.10724. (PMID: 29405276)
- 78 Scheurlen KM, Probst P, Kopf S. et al. Metabolic surgery improves renal injury independent of weight loss: a meta-analysis. Surg Obes Relat Dis 2019; 15: 1006-1020 DOI: 10.1016/j.soard.2019.03.013. (PMID: 31104957)
- 79 Cohen RV, Pereira TV, Aboud CM. et al. Effect of Gastric Bypass vs Best Medical Treatment on Early-Stage Chronic Kidney Disease in Patients With Type 2 Diabetes and Obesity: A Randomized Clinical Trial. JAMA Surg 2020; 155: e200420 DOI: 10.1001/jamasurg.2020.0420. (PMID: 32492126)
- 80 Billeter AT, Scheurlen KM, Israel B. et al. Gastric Bypass Resolves Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Low-BMI Patients: A Prospective Cohort Study. Ann Surg 2022; 276: 814-821 DOI: 10.1097/SLA.0000000000005631. (PMID: 35880762)
- 81 Wharton S, Lau DCW, Vallis M. et al. Obesity in adults: a clinical practice guideline. CMAJ 2020; 192: E875-E891 DOI: 10.1503/cmaj.191707. (PMID: 32753461)
- 82 Padwal RS, Pajewski NM, Allison DB. et al. Using the Edmonton Obesity Staging System to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 2011; 183: E1059-E1066
- 83 Schwarz AC, Billeter AT, Scheurlen KM. et al. Comorbidities as an Indication for Metabolic Surgery. Visc Med 2018; 34: 381-387 DOI: 10.1159/000493291. (PMID: 30498706)
- 84 Kuk JL, Ardern CI, Church TS. et al. Edmonton Obesity Staging System: association with weight history and mortality risk. Appl Physiol Nutr Metab 2011; 36: 570-576 DOI: 10.1139/h11-058. (PMID: 21838602)
- 85 Bueter M, Seyfried F, Germer CT. [Why Patients Lose Weight after Bariatric Operations]. Zentralbl Chir 2010; 135: 28-33 DOI: 10.1055/s-0029-1224697. (PMID: 20140853)
- 86 Cummings DE, Weigle DS, Frayo RS. et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623-1630 DOI: 10.1056/NEJMoa012908. (PMID: 12023994)
- 87 Basso N, Capoccia D, Rizzello M. et al. First-phase insulin secretion, insulin sensitivity, ghrelin, GLP-1, and PYY changes 72h after sleeve gastrectomy in obese diabetic patients: the gastric hypothesis. Surg Endosc 2011; 25: 3540-3550 DOI: 10.1007/s00464-011-1755-5. (PMID: 21638183)
- 88 Moreno-Arciniegas A, Falckenheiner-Soria J, Bancalero-De Los Reyes J. et al. The main participation of the enterohormone GLP-1 after bariatric surgery. Minerva Chir 2019; 74: 7-13 DOI: 10.23736/S0026-4733.18.07681-2. (PMID: 29963790)
- 89 Steinert RE, Feinle-Bisset C, Asarian L. et al. Ghrelin, CCK, GLP-1, and PYY (3–36): Secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB. Physiol Rev 2017; 97: 411-463 DOI: 10.1152/physrev.00031.2014. (PMID: 28003328)
- 90 Sumithran P, Prendergast L, Delbridge E. et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 2011; 365: 1597-1604 DOI: 10.1056/NEJMoa1105816. (PMID: 22029981)
- 91 Klein S, Krupka S, Behrendt S, Pulst A, Bleß HH. Weißbuch Adipositas – Versorgungssituation in Deutschland. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft; 2016 Accessed November 08, 2022 at: http://www.deutsches-netzwerk-adipositas.de/pdf/Weissbuch_Adipositas_2016.06.pdf
- 92 Jung FU, Luck-Sikorski C, König HH. et al. Stigma and Knowledge as Determinants of Recommendation and Referral Behavior of General Practitioners and Internists. Obes Surg 2016; 26: 2393-2401 DOI: 10.1007/s11695-016-2104-5. (PMID: 26886930)