Klin Monbl Augenheilkd 2024; 241(01): 95-101
DOI: 10.1055/a-2022-8462
Kasuistik

Bilateral Acute Macular Neuroretinopathy (AMN) after COVID-19 and its Clinical Course

Article in several languages: English | deutsch

Authors

  • Alexander Johannes Bartsch

    Augenklinik, Universitätsklinikum Erlangen, Deutschland
  • Adam Alexander Skornia

    Augenklinik, Universitätsklinikum Erlangen, Deutschland
  • Christian Yahya Mardin

    Augenklinik, Universitätsklinikum Erlangen, Deutschland
  • Bettina Hohberger

    Augenklinik, Universitätsklinikum Erlangen, Deutschland

Abstract

Acute macular neuroretinopathy (AMN) is a rare disease entity. It is mainly observed in young women with a history of influenza-like infection or who have been taking oral contraceptives for several years. Patients typically describe subjective visual deterioration and mono- or bilateral paracentral relative scotomas. In some cases, funduscopic ophthalmic examination may reveal subtle sharply demarcated flat lesions of reddish-brown or orange colour in the macular region. Diagnosis is usually made by near-infrared fundus imaging which shows hyporeflective areas, and SD-OCT imaging which manifests changes in the outer retinal layers. In the following, three patient cases with bilateral AMN are described which occurred in direct temporal relationship to a recent SARS-CoV-2 infection.



Publication History

Received: 11 October 2022

Accepted: 24 January 2023

Article published online:
08 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References/Literatur

  • 1 Ulhaq ZS, Soraya GV. The prevalence of ophthalmic manifestations in COVID-19 and the diagnostic value of ocular tissue/fluid. Graefes Arch Clin Exp Ophthalmol 2020; 258: 1351-1352
  • 2 Nasiri N, Sharifi H, Bazrafshan A. et al. Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis. J Ophthalmic Vis Res 2021; 16: 103-112
  • 3 Sawalha K, Adeodokun S, Kamoga GR. COVID-19-Induced Acute Bilateral Optic Neuritis. J Investig Med High Impact Case Rep 2020; 8: 232470962097601
  • 4 Walinjkar J, Makhija S, Sharma H. et al. Central retinal vein occlusion with COVID-19 infection as the presumptive etiology. Indian J Ophthalmol 2020; 68: 2572
  • 5 Jackson CB, Farzan M, Chen B. et al. Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol 2022; 23: 3-20
  • 6 Rokohl AC, Grajewski RS, Matos PAW. et al. Ocular Involvement in COVID-19: Conjunctivitis and More. Klin Monbl Augenheilkd 2021; 238: 555-560
  • 7 Bormann M, van de Sand L, Witzke O. et al. Recent Antiviral Treatment and Vaccination Strategies Against SARS-CoV-2. Klin Monbl Augenheilkd 2021; 238: 569-578
  • 8 Zhou L, Xu Z, Castiglione GM. et al. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. Ocul Surf 2020; 18: 537-544
  • 9 Casagrande M, Fitzek A, Püschel K. et al. Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients. Ocul Immunol Inflamm 2020; 28: 721-725
  • 10 Marinho PM, Marcos AAA, Romano AC. et al. Retinal findings in patients with COVID-19. Lancet 2020; 395: 1610
  • 11 Jalink MB, Bronkhorst IHG. A Sudden Rise of Patients with Acute Macular Neuroretinopathy during the COVID-19 Pandemic. Case Rep Ophthalmol 2022; 13: 96-103
  • 12 Bhavsar KV, Lin S, Rahimy E. et al. Acute macular neuroretinopathy: A comprehensive review of the literature. Surv Ophthalmol 2016; 61: 538-565
  • 13 Turbeville SD, Cowan LD, Gass JDM. Acute Macular Neuroretinopathy A Review of the Literature. Surv Ophthalmol 2003; 48: 1-11
  • 14 Drüke D, Pleyer U, Hoerauf H. et al. Acute macular neuroretinopathy (AMN) following COVID-19 vaccination. Am J Ophthalmol Case Rep 2021; 24: 101207
  • 15 Pawlik VE, Mohi A, Rommel F. et al. Transparente Darstellung von Kasuistiken nach COVID-19-Erkrankung oder COVID-19-Impfung – eine zeitliche Koinzidenz. Klin Monbl Augenheilkd 2022;
  • 16 Wyss A, Rüesch R, Schwizer N. et al. Akute makuläre Neuroretinopathie. Klin Monbl Augenheilkd 2019; 236: 555-561
  • 17 Huchzermeyer C, Bergua A. Eine sehr seltene und leicht zu übersehende Erkrankung der Makula. Klin Monbl Augenheilkd 2015; 232: 688-690
  • 18 Masjedi M, Pourazizi M, Hosseini N. Acute macular neuroretinopathy as a manifestation of coronavirus disease 2019: A case report. Clin Case Rep 2021; 9: e04976
  • 19 Oh S, Kim YJ, Lee EK. et al. Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model. Antioxidants 2020; 9: 833
  • 20 Bae M, Kim H. The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19. Molecules 2020; 25: 5346
  • 21 Strzalkowski P, Steinberg JS, Dithmar S. COVID-19-assoziierte akute makuläre Neuroretinopathie. Ophthalmologie 2022;
  • 22 Fawzi AA, Pappuru RR, Sarraf D. et al. Acute Macular Neuroretinopathy: Long-Term Insights Revealed by Multimodal Imaging. Retina 2012; 32: 1500-1513
  • 23 Neuhann IM, Inhoffen W, Koerner S. et al. Visualization and follow-up of acute macular neuroretinopathy with the Spectralis® HRA+OCT device. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1041-1044