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Am J Perinatol
DOI: 10.1055/a-2051-8544
Original Article

Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

Ufuk Cakir 
1   Division of Neonatology, Health Science University, Ankara Bilkent City Hospital, Ankara
,
Ali Ulas Tugcu
1   Division of Neonatology, Health Science University, Ankara Bilkent City Hospital, Ankara
,
Cuneyt Tayman
1   Division of Neonatology, Health Science University, Ankara Bilkent City Hospital, Ankara
,
Duran Yildiz
1   Division of Neonatology, Health Science University, Ankara Bilkent City Hospital, Ankara
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Abstract

Objective It is not yet known whether systemic inflammatory indices affect the development of respiratory distress syndrome (RDS) in premature infants. We aimed to evaluate the relationship between systemic inflammatory indices obtained on the first day of life and the development of RDS in premature infants.

Study Design Premature infants with gestational age of ≤32 weeks were included in the study. Six systemic inflammatory indices involving neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were measured in the first 1 hour after birth and compared in premature infants with and without RDS.

Results A total of 931 premature infants, 579 infants in the RDS group and 352 infants in the non-RDS group, were included in the study. MLR, PLR, and SIRI values were similar between the groups (p > 0.05 for all parameters). NLR, PIV, and SII values in the RDS group were significantly higher than those in the non-RDS group (p = 0.005, p = 0.011, and p < 0.001, respectively). In the predictivity of RDS, the AUC value of SII was 0.842 and the cut-off value was ≥78.200. Multiple logistic analysis showed that a higher level of SII (≥78.2) was independently associated with RDS (odds ratio: 3.03, 95% confidence interval: 1.761–5.301).

Conclusion Our results demonstrated that a higher SII level (≥78.2) may be a predictor for the development of RDS in premature infants with gestational age of ≤32 weeks.

Key Points

  • It is not yet known whether systemic inflammatory indices affect the development of RDS.

  • Our results demonstrated high SII levels may be a predictor for the development of RDS.

  • SII may provide an advantage as a low-cost, easy-to-detect, useful and powerful parameter in RDS.

Keywords

monocyte-to-lymphocyte ratio - neutrophil-to-lymphocyte ratio - pan-immune-inflammation value - platelet-to-lymphocyte ratio - premature - respiratory distress syndrome - systemic inflammation response index - systemic immune-inflammation index


Publication History

Received: 14 November 2022

Accepted: 24 February 2023

Accepted Manuscript online:
10 March 2023

Article published online:
17 April 2023

© 2023. Thieme. All rights reserved.

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