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Klin Monbl Augenheilkd 2023; 240(12): 1350-1358
DOI: 10.1055/a-2130-0546
Übersicht

Chromatische Pupillometrie – ein neuer Weg zur funktionellen Glaukomdiagnostik?

Article in several languages: English | deutsch

Authors

  • Cord Huchzermeyer 

    Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland
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Zusammenfassung

Die chromatische Pupillometrie erlaubt die Quantifizierung der photorezeptorvermittelten (extrinsischen) und der melanopsinvermittelten (intrinsischen) Antwort der intrinsisch-photosensitiven retinalen Ganglienzellen (ipRGCs). Diese kleine Subpopulation der Ganglienzellen wird beim Glaukom ebenfalls geschädigt, und somit ist die chromatische Pupillometrie für die Glaukomdiagnostik potenziell interessant. Die bisherigen Studien zeigen sowohl eine Verminderung der phasischen Antwort als auch der tonischen Antwort beim Glaukom. Die diagnostische Wertigkeit unterschied sich abhängig von der verwendeten Technik und dem Studiendesign. Der vorliegende Artikel soll vor allem die Grundlagen der chromatischen Pupillometrie und die potenziellen Anwendungen beim Glaukom darstellen.

Schlüsselwörter

Glaukom - Pupillometrie - retinale Ganglienzellen - Neuroophthalmologie


Publication History

Received: 20 June 2023

Accepted: 04 July 2023

Article published online:
07 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References/Literatur

  • 1 Casson RJ, Chidlow G, Wood JPM. et al. Definition of glaucoma: clinical and experimental concepts. Clin Experiment Ophthalmol 2012; 40: 341-349
    Search in Google Scholar
  • 2 Camp AS, Weinreb RN. Will Perimetry Be Performed to Monitor Glaucoma in 2025?. Ophthalmology 2017; 124 (12S): S71-S75
    Search in Google Scholar
  • 3 Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res 2007; 26: 688-710
    Search in Google Scholar
  • 4 Lämmer R, Huchzermeyer C. [Value of Perimetric Measurements for Glaucoma Detection]. Klin Monbl Augenheilkd 2021;
    Search in Google Scholar
  • 5 Fry LE, Fahy E, Chrysostomou V. et al. The coma in glaucoma: Retinal ganglion cell dysfunction and recovery. Prog Retin Eye Res 2018; 65: 77-92
    Search in Google Scholar
  • 6 Bach M, Brigell MG, Hawlina M. et al. ISCEV standard for clinical pattern electroretinography (PERG): 2012 update. Doc Ophthalmol 2013; 126: 1-7
    Search in Google Scholar
  • 7 Frishman L, Sustar M, Kremers J. et al. ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram. Doc Ophthalmol 2018; 136: 207-211
    Search in Google Scholar
  • 8 Dacey DM. Parallel pathways for spectral coding in primate retina. Annu Rev Neurosci 2000; 23: 743-775
    Search in Google Scholar
  • 9 Kim US, Mahroo OA, Mollon JD. et al. Retinal Ganglion Cells – Diversity of Cell Types and Clinical Relevance. Front Neurol 2021; 12: 661938
    Search in Google Scholar
  • 10 Rodiek RW. The First Steps in Seeing. Sunderland, Massachusetts: Sinauer Associates, Inc.; 1998
    Search in Google Scholar
  • 11 Lee BB, Sun H, Zucchini W. The temporal properties of the response of macaque ganglion cells and central mechanisms of flicker detection. J Vis 2007;
    Search in Google Scholar
  • 12 Sample PA. Short-wavelength automated perimetry: itʼs role in the clinic and for understanding ganglion cell function. Prog Retin Eye Res 2000; 19: 369-383
    Search in Google Scholar
  • 13 Anderson AJ, Johnson CA. Frequency-doubling technology perimetry. Ophthalmol Clin North Am 2003; 16: 213-225
    Search in Google Scholar
  • 14 Frisén L. New, sensitive window on abnormal spatial vision: rarebit probing. Vision Res 2002; 42: 1931-1939
    Search in Google Scholar
  • 15 Frisén L. High-pass resolution perimetry. A clinical review. Doc Ophthalmol 1993; 83: 1-25
    Search in Google Scholar
  • 16 Swanson WH, Sun H, Lee BB. et al. Responses of Primate Retinal Ganglion Cells to Perimetric Stimuli. Invest Ophthalmol Vis Sci 2011; 52: 764-771
    Search in Google Scholar
  • 17 Quigley HA, Dunkelberger GR, Green WR. Chronic human glaucoma causing selectively greater loss of large optic nerve fibers. Ophthalmology 1988; 95: 357-363
    Search in Google Scholar
  • 18 Johnson CA. Selective versus nonselective losses in glaucoma. J Glaucoma 1994; 3 (Suppl. 01) S32-S44
    Search in Google Scholar
  • 19 Dacey DM, Liao HW, Peterson BB. et al. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature 2005; 433: 749-754
    Search in Google Scholar
  • 20 Rukmini AV, Milea D, Aung T. et al. Pupillary responses to short-wavelength light are preserved in aging. Sci Rep 2017; 7: 43832
    Search in Google Scholar
  • 21 Feigl B, Mattes D, Thomas R. et al. Intrinsically photosensitive (melanopsin) retinal ganglion cell function in glaucoma. Invest Ophthalmol Vis Sci 2011; 52: 4362-4367
    Search in Google Scholar
  • 22 Obara EA, Hannibal J, Heegaard S. et al. Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients. Invest Ophthalmol Vis Sci 2016; 57: 4661-4667
    Search in Google Scholar
  • 23 Li RS, Chen BY, Tay DK. et al. Melanopsin-Expressing Retinal Ganglion Cells Are More Injury-Resistant in a Chronic Ocular Hypertension Model. Invest Ophthalmol Vis Sci 2006; 47: 2951-2958
    Search in Google Scholar
  • 24 Honda S, Namekata K, Kimura A. et al. Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma. Invest Ophthalmol Vis Sci 2019; 60: 3696-3707
    Search in Google Scholar
  • 25 Kelbsch C, Strasser T, Chen Y. et al. Standards in Pupillography. Front Neurol 2019; 10: 129
    Search in Google Scholar
  • 26 Suo L, Zhang D, Qin X. et al. Evaluating State-of-the-Art Computerized Pupillary Assessments for Glaucoma Detection: A Systematic Review and Meta-Analysis. Front Neurol 2020; 11: 777
    Search in Google Scholar
  • 27 Najjar RP, Rukmini AV, Finkelstein MT. et al. Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma. Br J Ophthalmol 2023; 107: 663-670
    Search in Google Scholar
  • 28 Huchzermeyer C, Kremers J. Selective Stimulation of the Different Photoreceptor Classes by Silent Substitution in Psychophysical and Electroretinographic Measurements. Klin Monbl Augenheilkd 2022; 239: 1433-1439
    Search in Google Scholar
  • 29 Zele AJ, Adhikari P, Cao D. et al. Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response. Front Neurol 2019; 10: 529
    Search in Google Scholar
  • 30 Yoshikawa T, Obayashi K, Miyata K. et al. Association Between Postillumination Pupil Response and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study. Invest Ophthalmol Vis Sci 2022; 63: 24
    Search in Google Scholar
  • 31 Ramirez AI, de Hoz R, Salobrar-Garcia E. et al. The Role of Microglia in Retinal Neurodegeneration: Alzheimerʼs Disease, Parkinson, and Glaucoma. Front Aging Neurosci 2017; 9: 214
    Search in Google Scholar
  • 32 Gracitelli CPB, Duque-Chica GL, Moura AL. et al. A positive association between intrinsically photosensitive retinal ganglion cells and retinal nerve fiber layer thinning in glaucoma. Invest Ophthalmol Vis Sci 2014; 55: 7997-8005
    Search in Google Scholar
  • 33 Kelbsch C, Maeda F, Strasser T. et al. Pupillary responses driven by ipRGCs and classical photoreceptors are impaired in glaucoma. Graefes Arch Clin Exp Ophthalmol 2016; 254: 1361-1370
    Search in Google Scholar
  • 34 Quan Y, Duan H, Zhan Z. et al. Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry. Ophthalmol Ther 2023; 12: 2133-2156
    Search in Google Scholar
  • 35 Rukmini AV, Milea D, Baskaran M. et al. Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity. Ophthalmology 2015; 122: 1777-1785
    Search in Google Scholar
  • 36 Adhikari P, Zele AJ, Thomas R. et al. Quadrant Field Pupillometry Detects Melanopsin Dysfunction in Glaucoma Suspects and Early Glaucoma. Sci Rep 2016; 6: 33373
    Search in Google Scholar
  • 37 Kelbsch C, Stingl K, Kempf M. et al. Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects. Transl Vis Sci Technol 2019; 8: 19
    Search in Google Scholar
  • 38 Kelbsch C, Stingl K, Jung R. et al. How lesions at different locations along the visual pathway influence pupillary reactions to chromatic stimuli. Graefes Arch Clin Exp Ophthalmol 2022; 260: 1675-1685
    Search in Google Scholar