Maternal Preconception Omega-6, Omega-3, and Omega-6:Omega-3 Intake and Uterine Artery Indices in Mid-Gestation

Amara Finch; Lisa Joss-Moore; Amanda A. Allshouse; Nathan Blue; David M. Haas; William Grobman; Samuel Parry; George Saade; Robert M. Silver

doi:10.1055/a-2351-9810

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2025; 42(03): 310-319
DOI: 10.1055/a-2351-9810

Original Article

Maternal Preconception Omega-6, Omega-3, and Omega-6:Omega-3 Intake and Uterine Artery Indices in Mid-Gestation

Amara Finch

¹Department of Pediatrics, University of Utah, Salt Lake City, Utah

,

Lisa Joss-Moore

¹Department of Pediatrics, University of Utah, Salt Lake City, Utah

,

Amanda A. Allshouse

²Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah

,

Nathan Blue

²Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah

³Department of Obstetrics and Gynecology, Intermountain Healthcare, Murray, Utah

,

David M. Haas

⁴Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana

,

William Grobman

⁵Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio

,

Samuel Parry

⁶Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania

,

George Saade

⁷Department of Obstetrics and Gynecology, East Virginia Medical School, Norfolk, Virginia

,

Robert M. Silver

²Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah

³Department of Obstetrics and Gynecology, Intermountain Healthcare, Murray, Utah

› Institutsangaben

Abstract

Objective Maternal preconception diet influences pregnancy health and fetal outcomes. We examined the relationship between preconception fatty acid (FA) intake and uterine artery indices in mid-gestation in a large, heterogeneous cohort of nulliparous individuals.

Study Design This is a secondary analysis of the nuMom2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be) study. Dietary ω-6 and ω-3 FA intake was assessed with food frequency questionnaires and uterine artery indices were obtained via Doppler studies in the second trimester. For our primary outcome of pulsatility index (PI) > 1.6, we compared proportions by each dichotomous FA exposure and tested differences with chi-square test.

Results For PI > 1.6, odds ratio for the unfavorable FA quartile compared with remaining quartiles for the exposures were 0.96 to 1.25, p = 0.157 (ω-6 FA); 0.97 to 1.26, p = 0.124 (ω-3 FA); 0.87 to 1.14, p = 1.00 (ω-6:ω-3 FA ratio).

Conclusion No significant associations between self-reported maternal preconception ω-6 and ω-3 FA intake and uterine artery Doppler indices measured during the second trimester were observed.

Key Points

Maternal diet impacts pregnancy health/fetal outcomes.
ω-3 and ω-6 FA intake influences cardiovascular health.
FA intake may affect blood flow to fetoplacental unit.
Results are limited by inadequate adherence to dietary recommendations.

Keywords

maternal nutrition - essential fatty acids - fetal development - periconception health - uterine artery blood flow

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Referenzen

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