Displacement of a Water Molecule Enhances Drug Residence

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Synfacts 2024; 20(12): 1314
DOI: 10.1055/a-2439-7932

Innovative Drug Discovery and Development

Contributor(s):

Antonia F. Stepan (Roche)

,

Nicholas A. Meanwell (Baruch S. Blumberg Institute, U. Michigan, Rutgers U.)

Keywords

drug binding kinetics - residence time - water displacement - bioisostere

Article published online:
21 November 2024

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany