Open Access
CC BY-NC-ND 4.0 · Am J Perinatol 2025; 42(09): 1223-1228
DOI: 10.1055/a-2483-5684
Clinical Opinion

Fetal Growth Restriction: A Pragmatic Approach

1   Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
,
Malavika Prabhu
1   Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
,
Anjali Kaimal
2   Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, Florida
› Author Affiliations

Funding None.
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Abstract

An accurate diagnosis of fetal growth restriction relies on a precise estimation of gestational age based on a carefully obtained history as well as early ultrasound, since a difference of just a few days can lead to a significant error. There is a continuum of risk for adverse outcome that depends on the certainty of dates and presence or absence of comorbidities, in addition to the estimated fetal weight percentile and the umbilical artery waveform. The results of several studies, most notably the TRUFFLE trial, demonstrate that optimal management of fetal growth restriction with an abnormal umbilical artery waveform requires daily electronic fetal heart rate monitoring, and this monitoring does not require computerized interpretation. The role of ductus venosus waveform, biophysical profile, and middle cerebral artery waveform is less clear, and the results of these three modalities should be interpreted with caution.

Key Points

  • A correct diagnosis of fetal growth restriction requires a very precise estimate of gestational age.

  • In the presence of abnormal umbilical artery Doppler, the cornerstone of surveillance is daily electronic fetal heart rate monitoring.

  • Surveillance with biophysical profile, ductus venosus waveform, and middle cerebral artery waveform are less important than daily electronic fetal heart rate monitoring.



Publication History

Received: 26 October 2024

Accepted: 20 November 2024

Accepted Manuscript online:
25 November 2024

Article published online:
24 December 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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