Abstract
Objective
This study aimed to describe feeding outcomes in neonates with hypoxic-ischemic encephalopathy
(HIE) and compare characteristics and outcomes in groups discharged home on oral,
total/partial nasogastric, and gastrostomy tube feedings.
Study Design
This was a retrospective, single-center cohort study of infants diagnosed with moderate
or severe HIE using standard criteria who underwent cooling from January 2017 to June
2022. Data were abstracted from hospital course as well as until 6 months follow-up.
Statistical analysis included chi-square test and ANOVA with post hoc Bonferroni correction
for between-group comparisons.
Results
Among 123 included infants, 95 (77%) fed orally, 11 (9%) required total/partial nasogastric
feeds and 17 (14%) had gastrostomy tubes at discharge. A significantly greater proportion
of infants with gastrostomy-tube feeds at discharge had intrapartum complications,
Apgar scores <5 at 5 and 10 minutes, severe rather than moderate HIE, and seizures.
They also had a longer hospital stay, prolonged respiratory support and intubated
days, and delayed initiation of feeding. Infants discharged on nasogastric feeds all
attained oral feeds at a median (IQR) duration of 54 (6–178) days follow-up. Among
the 106 (86%) infants with follow-up data, the gastrostomy group had significantly
lower median weight and head circumference centiles compared to the others. Criteria
for gavage eligibility were met before discharge in 98 (80%) of the cohort; 42% stayed
beyond this benchmark.
Conclusion
Earlier identification of eventual gastrostomy tube insertion as well as discharge
home on nasogastric feedings may reduce duration of hospitalization in infants with
HIE. Our data may provide insights to guide practice improvement for enteral feedings
in this population.
Key Points
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In neonatal encephalopathy, impaired oral feedings is common.
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Antepartum complications and HIE severity are associated with gastrostomy insertion.
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Discharge home on gavage feeds could shorten hospital stay.
Keywords
hypoxic-ischemic encephalopathy - enteral - feeding - gastrostomy - nasogastric
