A Tale of Drug Discovery: Synthesis, Bioassay, and Computational Docking Studies of Novel Curcuminoids

Abstract

With the goal to overcome the bio-physicochemical drawbacks of parent curcumin (CUR) and to develop analogues with improved biological profiles and higher potencies, the present account provides a review summary of the work in my laboratory on the synthesis of structurally diverse libraries of curcuminoids (CURs), their in vitro bioassays, and computational docking studies. These efforts resulted in the discovery of a subset of compounds with exceptional antiproliferative and apoptotic activity that warrant further investigation.

1 Introduction

2 Synthetic Strategies

3 Bioassay Studies

4 Computational Docking Studies

5 Summary and Outlook

Key words

novel curcuminoids - synthesis - in vitro bioassay - anticancer activity - computational docking

Publikationsverlauf

Eingereicht: 10. März 2025

Angenommen nach Revision: 07. Mai 2025

Accepted Manuscript online:
07. Mai 2025

Artikel online veröffentlicht:
09. Juli 2025

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