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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd
DOI: 10.1055/a-2651-4971
GebFra Science
Original Article

Interpregnancy Interval as a Determinant of Outcome in Women with Prophylactic Cerclage Following Preterm Birth or Late Miscarriage

Artikel in mehreren Sprachen: English | deutsch

Authors

  • Filiz Markfeld-Erol 

    1   Klinik für Frauenheilkunde, Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany (Ringgold ID: RIN127713)

  • Aaron Riedling

    2   Quantitative Biology Center (QBIC), Universität Tübingen, Tübingen, Germany (Ringgold ID: RIN54188)

  • Ingolf Juhasz-Böss

    1   Klinik für Frauenheilkunde, Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany (Ringgold ID: RIN127713)

  • Mirjam Kunze

    1   Klinik für Frauenheilkunde, Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany (Ringgold ID: RIN127713)

  • Julia Meschede

    1   Klinik für Frauenheilkunde, Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany (Ringgold ID: RIN127713)
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Abstract

Background

Patients with a history of late miscarriage or preterm birth in a previous pregnancy may have a cerclage with total cervical closure (TCC) in a subsequent pregnancy to increase the likelihood of term delivery. This analysis investigates whether the interpregnancy interval influences the outcome of the subsequent pregnancy.

Methods

In a retrospective cohort of 131 women who received a prophylactic cerclage with TCC following late miscarriage or preterm birth, the impact of the interpregnancy interval on pregnancy outcome was evaluated. Women were divided into three interpregnancy interval groups (0–6, 6–12, and > 12 months). Outcomes assessed included late miscarriage, preterm birth (stratified by gestational age), term birth (≥ 37+0 weeks of gestation), and neonatal parameters (Apgar scores, umbilical cord pH, birth weight, and admission to the neonatal intensive care unit [NICU]).

Results

An interpregnancy interval of more than 12 months was associated with the highest rate of term deliveries (85.4%) and the best neonatal outcomes overall. This group had the lowest NICU admission rates, the highest birth weights, and the best Apgar scores. Very early preterm births (< 28+0 weeks) were observed more frequently in the shorter interval groups. Umbilical artery pH showed no correlation with the interpregnancy interval.

Conclusion

A longer interpregnancy interval of more than 12 months was associated with a higher rate of deliveries ≥ 37+0 weeks and improved fetal outcomes in women with prophylactic cerclage and TCC after prior preterm birth or late miscarriage. In contrast, very early preterm births (< 28+0 weeks) occurred more often with shorter intervals.

Keywords

cerclage - interpregnancy interval - premature birth - cervical insufficiency - late miscarriage


Publikationsverlauf

Eingereicht: 02. Mai 2025

Angenommen nach Revision: 07. Juli 2025

Artikel online veröffentlicht:
29. August 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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