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Synlett
DOI: 10.1055/a-2694-6852
DOI: 10.1055/a-2694-6852
Letter
Alkynes in Organic Synthesis
Hydroformylation of Protected Propargylic Alcohols
Abstract
A rhodium catalyst modified with a self-assembling pyridone-based phosphine ligand enables a chemoselective hydroformylation of protected propargylic alcohols to furnish either 4-siloxy enals or protected 4-hydroxy aldehydes depending on the reaction conditions.
Keywords
Hydroformylation - Alkynes, Rhodium Catalysis - Propargylic Alcohols - Self-assembling Ligands, Enals - SilylethersPublication History
Received: 03 July 2025
Accepted after revision: 28 August 2025
Article published online:
18 September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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