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Synlett
DOI: 10.1055/a-2705-8764
Letter

Heterobenzylic C(sp³)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy

Karthick Muthuvel
1   Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)
,
Chandrasekaran Sivaraj
1   Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)
,
Thirumanavelan Gandhi
1   Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)
› Author Affiliations
Supported by: The Department of Science and Technology-SERB, India CRG/2021/001143
Supported by: Vellore Institute of Techmology SG20210167
Supported by: Council of Scientific and Industrial Research (CSIR), New Delhi, India 09/0844(18215)/2024-EMR-I
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Heterobenzylic C(sp3)−H functionalization of isoindolinones remains challenging yet highly desirable. Herein, we present a photo-induced hydrogen atom transfer (HAT) strategy for heterobenzylic C(sp3)−H acylation of isoindolinones using acyl azolium salts under mild reaction conditions. This metal-free protocol offers excellent functional group compatibility and avoids the usage of Lewis acids or oxidants, providing a sustainable and efficient approach to C–H acylation.



Publication History

Received: 12 June 2025

Accepted after revision: 28 August 2025

Accepted Manuscript online:
19 September 2025

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