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Synlett
DOI: 10.1055/a-2706-0684
Letter

Rapid deprotection of O-allyoxycarbonyl(alloc) alcohols by NiCl2•6H2O and NaBH4

Xinxin Yuan 
1   Pharmacy, East China University of Science and Technology, Shanghai, China (Ringgold ID: RIN47860)
,
Qian ding Zeng
1   Pharmacy, East China University of Science and Technology, Shanghai, China (Ringgold ID: RIN47860)
,
Hongmiao Yao 
1   Pharmacy, East China University of Science and Technology, Shanghai, China (Ringgold ID: RIN47860)
,
Wen jun Jin
2   ehs department, Zhejiang Xianju Pharmaceutical Co Ltd, Taizhou, China (Ringgold ID: RIN371890)
,
Jiangmeng Ren 
3   School of Pharmacy, East China University of Science and Technology, Shanghai, China (Ringgold ID: RIN47860)
,
Bu-Bimg Zeng
4   Scholl of Pharmacy, East China University of Science and Technology, Shanghai, China (Ringgold ID: RIN47860)
› Author Affiliations
Supported by: National Natural Science Foundation of China Grant U23A20530
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A novel protocol for the deprotection of O-allyloxycarbonyl(alloc) group by nickel(II) chloride hexahydrate with sodium borohydride in acetone at 0 ºC to give the corresponding parent alcohols and phenols in high yields was demonstrated. This method had the advantages of mild reaction condition and broad substrate scope. The deprotection had also been validated in gram scale, to establish its appropriateness of this protocol.



Publication History

Received: 06 July 2025

Accepted after revision: 01 September 2025

Accepted Manuscript online:
19 September 2025

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