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DOI: 10.1055/a-2706-0684
Rapid Deprotection of O-Allyoxycarbonyl(alloc) Alcohols by NiCl2•6H2O and NaBH4
Authors
Grant U23A20530
Funding Information This work was supported by Grant U23A20530.
Abstract
A novel protocol for the deprotection of the O-allyloxycarbonyl(alloc) group by nickel(II) chloride hexahydrate with sodium borohydride in acetone at 0 °C to give the corresponding parent alcohols and phenols in high yields was demonstrated. This method had the advantages of mild reaction conditions and broad substrate scope. The deprotection had also been validated in gram scale, to establish the appropriateness of this protocol.
Keywords
Deprotection - O-Allyloxycarbonyl - Nickel(II) chloride hexahydrate - Sodium borohydride - Broad substrate scopePublication History
Received: 06 July 2025
Accepted after revision: 01 September 2025
Accepted Manuscript online:
19 September 2025
Article published online:
24 October 2025
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