Nickel-Catalyzed Enantioconvergent Cycloadditions of Aziridines and Imines

Abstract

We report asymmetric nickel-catalyzed cycloadditions of aziridines and imines enabled by a newly designed tyrosine-derived FOXAP ligand, delivering up to 97% ee and >20:1 dr. The reaction constructs imidazolidines bearing two nonadjacent stereocenters from racemic vinylaziridines and achiral imines in an enantioconvergent manner.

Keywords

Cycloaddition - Nickel - Enantioselectivity - Heterocycles - Enantioconvergent

Publikationsverlauf

Eingereicht: 13. September 2025

Angenommen nach Revision: 30. September 2025

Artikel online veröffentlicht:
31. Oktober 2025

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