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Synlett
DOI: 10.1055/a-2738-7947
Letter

Catalytic Cyanation of Aryl halides with Electrophilic N-CN reagent

Authors

  • Murugan Dhanalakshmi

    1   Department of Chemistry, Indian Institute of Technology Madras, Chennai, India (Ringgold ID: RIN37268)

  • Pazhamalai Anbarasan 

    1   Department of Chemistry, Indian Institute of Technology Madras, Chennai, India (Ringgold ID: RIN37268)

Supported by: Science and Engineering Research Board SB/SJF/2020-21/15
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The palladium catalyzed cyanation of aryl halides has been accomplished for the synthesis of aryl nitriles using electrophilic N-CN reagent as a cyanating reagent. The method utilizes mild base and substoichiometric amount of zinc as promotor and offers mild cyanation that tolerates various functional groups to afford aryl nitriles in good to excellent yields. Preliminary mechanistic investigation revealed the important role of methylene linkage and reductant.



Publication History

Received: 11 September 2025

Accepted after revision: 04 November 2025

Accepted Manuscript online:
04 November 2025

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