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Synlett
DOI: 10.1055/a-2797-9503
Letter

Ruthenium-catalyzed C–H Sulfonamidation of 4-Aryl-7H-pyrrolo[2,3-d] pyrimidine with Sulfonyl Azides Under Aerobic Atmosphere

Authors


This work was supported by National Natural Science Foundation of China (No. 22277108, 21877099). Zhejiang Apeloa Pharmaceutical Co., Ltd. (No. KYY-HX-20200894), and Hangzhou Keysensing Co., Ltd. (No. KYY-HX-20241).
Supported by: National Natural Science Foundation of China 22277108, 21877099 Supported by: Zhejiang Apeloa Pharmaceutical Co., Ltd. KYY-HX-20200894
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Graphical Abstract

Abstract

Ruthenium-catalyzed arene ortho C−H sulfonamidation of 4-aryl-7H-pyrrolo[2,3-d]pyrimidine derivatives with sulfonyl azides under aerobic conditions is described. This transformation has the advantages of operational simplicity, good functional group compatibility, broad substrate scope, and mild conditions, affording a variety of sulfonamidated pyrrolo[2,3-d]pyrimidine derivatives in good to excellent yields. Oxygen plays a vital role in this unique reactivity.

Keywords

C–H sulfonamidation - Pyrrolo[2,3-d]pyrimidine - Sulfonyl azides - Site-selectivity - [RuCl2(p-cymene)]2 - Under aerobic conditions


Publication History

Received: 19 December 2025

Accepted after revision: 26 January 2026

Accepted Manuscript online:
27 January 2026

Article published online:
06 February 2026

© 2026. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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