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Dendritic Effect of Supported Proline-Based Catalysts for Aldol Reaction
K. Goren, T. Kehat, M. Portnoy*
Tel Aviv University, Israel
23 March 2009 (online)
The dendritic effect of polystyrene-supported proline analogues as heterogeneous organocatalysts for asymmetric aldol reaction was described. Analogues of the G2-catalytic dendron were prepared and used for the aldol reaction of benzaldehyde (R = H, NO2) with acetone (27 equiv). The fully dendritic G2(Pro) gave the higher yield (94%) and enantioselectivity (84%).