Download PDF
Synfacts 2009(4): 0419-0419  
DOI: 10.1055/s-0028-1087871
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium/Me-CATPHOS-Catalyzed Hydrogenation

Contributor(s): Hisashi Yamamoto, Pingfan Li
S. Doherty*, C. H. Smyth*, A. Harriman, R. W. Harrington, W. Clegg
Newcastle University, UK
Further Information

Publication History

Publication Date:
23 March 2009 (online)

    Permissions and Reprints

Significance

The novel atropos enantiopure 1,3-butadiene-bridged diphosphine ligand is prepared in a very short and efficient way. The performance of this ligand is better than BINAP and other phosphine ligands for a couple of rhodium-catalyzed hydrogenation reactions of dehydroamino acid derivatives.